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Validation of a confirmatory method of salbutamol in sheep hair by UPLC-MS/MS and its application to pharmacokinetic study

文献类型： 外文期刊

作者： Suo Decheng 1 ; Zhang Wei 1 ; Zhang Yu 1 ; Zhao Genlong 1 ; Wang Ruigou 1 ; Wang PeiLong 1 ; Su Xiaoou 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agr Prod, Beijing 100193, Peoples R China

关键词： Salbutamol;Sheep hair;UPLC-MS/MS;Pharmacokinetic study in sheep

期刊名称：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS （ 影响因子：3.935； 五年影响因子：3.563 ）

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收录情况： SCI

摘要： A new method for determining salbutamol in hair of sheep by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was established. Samples were extracted with 0.1 M of HCl solution. The mixture was heated to 60 degrees C in a water bath and kept at this temperature for 4 h. The extracts were purified through SPE method and then dried with nitrogen. Residues were redissolved in mobile phase. The target compound was determined by UPLC-MS/MS with BEH-C18 column. The usefulness and feasibility of different treatment procedures of hair containing salbutamol were evaluated. The range of linearity was 1-100 ng/g. The LOD was 0.3 ng/g, and the LOQ was 1 ng/g. Recoveries were 89-106%, and coefficients of variation were 3.2-13.9%. Pharmacokinetics of salbutamol was studied in healthy sheep after oral administration of 150 mu g/kg body weight salbutamol for 21 consecutive days. Salbutamol residues in hair were still detected after 21 days of administration. (C) 2015 Elsevier B.V. All rights reserved.

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