Estimating danofloxacin withdrawal time in broiler chickens based on physiologically based pharmacokinetics modeling
文献类型： 外文期刊
作者： Yang, F. 1 ; Sun, N. 2 ; Liu, Y. M. 3 ; Zeng, Z. L. 4 ;
作者机构： 1.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Luoyang, Peoples R China
2.Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun, Peoples R China
3.Chinese Acad Agr Sci, Feed Res Inst, Beijing 100193, Peoples R China
4.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China
期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）
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收录情况： SCI
摘要： In this study, a physiologically based pharmacokinetics (PBPK) model was firstly developed for danofloxacin in healthy broiler chickens after a single oral administration at 5mg/kg bw. Then, the model extrapolation from healthy chickens to those infected with Pasteurella multocidaones was performed. The healthy model was validated through a comparison of predicted and previously published concentrations, which indicated that the healthy PBPK model had good predictive ability in plasma, lung, muscle, liver, and kidney, especially at the later sampling time points. Multiple dosing of administration was incorporated into the healthy and infected models. In addition, a Monte Carlo simulation (MCS) included 1000 iterations was further incorporated into both models to predict the withdrawal times of danofloxacin in healthy and infected chickens, which were estimated to be 3 and 2days, respectively.
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