The roles of cytochrome P450 and P-glycoprotein in the pharmacokinetics of florfenicol in chickens
文献类型： 外文期刊
作者：
Wang, G. Y.
1
;
Zheng, H. H.
3
;
Zhang, K. Y.
3
;
Yang, F.
1
;
Kong, T.
1
;
Zhou, B.
1
;
Jiang, Sh. X.
2
;
作者机构： 1.Henan Univ Sci & Technol, Dept Basic Vet Med, Anim Coll Sci & Technol, Luoyang 471023, Peoples R China
2.Nanjing Agr Univ, Lab Vet Pharmacol & Toxicol, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China
3.Chinese Acad Agr Sci, Key Lab Vet Chem Drugs & Pharmaceut, Minist Agr, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China
关键词： CYP 1A; CYP 3A; Florfenicol; P-glycoprotein; pharmacokinetics
期刊名称：IRANIAN JOURNAL OF VETERINARY RESEARCH （ 影响因子：1.376； 五年影响因子：1.346 ）
ISSN： 1728-1997
年卷期： 2018 年 19 卷 1 期
页码：
收录情况： SCI
摘要： The effects of three selective oral inhibitors, fluvoxamine (FLU), ketoconazole (KET), and verapamil (VER), on the pharmacokinetics (PK) of florfenicol (FFC) were investigated in chickens. The chickens were administered orally with saline solution (SAL), FLU (60 mg/kg), KET (25 mg/kg), or VER (9 mg/kg) for 7 consecutive days. Florfenicol was given to the chickens at a single dose of 30 mg/kg orally. Blood samples were collected from each chicken at 0 to 12 h post-administration of FFC. The plasma concentration of FFC was analyzed by high-performance liquid chromatography (HPLC). The AUC of FFC increased and the CLs of FFC decreased with oral co-administration of KET in chickens, and the C-max of FCC increased with VER. While the AUC, the CLs and the C-max FFC were all invariable with FLU. These data suggested that CYP 3A played a key role in the PK of FFC in chickens, however, P-glycoprotein (P-gp) and CYP 1A did not. The results imply that the adverse drug-drug interaction may occur in the use of FFC if the co-administrated drugs are the substrates, inducers or inhibitors of CYP 3A or/and P-gp.
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