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The Cognitive-Enhancing Effects of Dendrobium nobile Lindl Extract in Sleep Deprivation-Induced Amnesic Mice

文献类型： 外文期刊

作者： Jiang, Ning 1 ; Li, Yu-jiao 1 ; Wang, Meng-di 1 ; Huang, Hong 2 ; Chen, Shanguang 3 ; Li, Yinghui 3 ; Qu, Lina 3 ; Wang, Fengzhong 4 ; Liu, Xinmin 1 ; Wang, Qiong 1 ;

作者机构： 1.Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Sino Portugal TCM Int Cooperat Ctr, Luzhou, Peoples R China

2.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing, Peoples R China

3.Chinese Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Natl Key Lab Human Factors Engn, Beijing, Peoples R China

4.Chinese Acad Agr Sci CAAS, Inst Food Sci & Technol, Beijing, Peoples R China

关键词： Dendrobium nobile Lindl; sleep deprivation; learning and memory; neurotransmitters (5-HT and NE); oxidative stress markers 3

期刊名称：FRONTIERS IN PSYCHIATRY （ 影响因子：5.435； 五年影响因子：5.556 ）

ISSN： 1664-0640

年卷期： 2022 年 12 卷

页码：

收录情况： SCI

摘要： Chronic sleep deprivation (SD) causes neurological and neurodegenerative dysfunction including learning and memory deficit. The orchid Dendrobium nobile Lindl (DNL), is widely used as a Yin tonic and medicinal food throughout Asia, and has many reported pharmacological effects. This study focused on the cognitive-enhancing effects of DNL in sleep deprivation-induced amnesia in mice and its biochemical mechanisms. Our results showed that the mice displayed significant cognitive deficits after 2-week SD while treatment with the extract of DNL prevented these impairments. In the novel object recognition and object location recognition tasks, a significant increase in the discrimination index was observed in DNL-treated (200 and 400 mg/kg) mice. In the MWM test, DNL (200 and 400 mg/kg) treatment shorten the prolongation of latency and increased the crossing numbers compared with SD mice. The biochemical analysis of brain tissue showed a decrease in NE, dismutase (T-SOD) and catalase (CAT) activity and an increase in 5-HT and malondialdehyde (MDA) concentration after the treatment with DNL in mice. Our findings indicated that DNL exerted a positive effect in preventing and improving cognitive impairment induced by SD, which may be mediated via the regulation of neurotransmitters and alleviation of oxidative stress.

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