Matrine-Type Alkaloids with Anti-Tomato Spotted Wilt Virus Activity from the Root of Sophora tonkinensis Gagnep.
文献类型： 外文期刊
作者： Zhao, Li-Hua 1 ; Hu, Zhan-Xing 2 ; Hao, Xiao-Jiang 2 ; Zhang, Peng 2 ; Zhang, Ji 2 ; An, Qiao 2 ; Wang, Juan 2 ; Yi, Ping 2 ; Yuan, Chun-Mao 2 ; Zhang, Zhong-Kai 1 ;
作者机构： 1.Yunnan Acad Agr Sci, Inst Biotechnol & Germplasm Resources, Kunming 650204, Peoples R China
2.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China
3.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
4.Chinese Acad Med Sci, Res Unit Chem Biol Nat Antivirus Prod, Kunming 650201, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources Wes, Kunming 650201, Peoples R China
6.Guizhou Univ Tradit Chinese Med, Sch Pharm, Guiyang 550025, Peoples R China
7.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Peoples R China
关键词： Sophora tonkinensis Gagnep; matrine-type alkaloids; anti-TSWV
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）
ISSN： 0021-8561
年卷期： 2023 年 71 卷 10 期
页码：
收录情况： SCI
摘要： As a continuation of our research on the development of pesticide active quinolizidine alkaloids (QAs) from the family Fabaceae, the chemical constituents of the root of Sophora tonkinensis Gagnep. were systematically investigated. Seventeen new matrine-type alkaloids (1-17), including one new naturally occurring compound (17), along with 20 known ones were isolated from the EtOH extract of S. tonkinensis. Notably, compound 5 possessed an unprecedented 6/6/5/4/6/6 hexacyclic system. Their structures were confirmed via comprehensive spectroscopic data analysis (IR, UV, NMR, HRESIMS), ECD calculation, and X-ray crystallography. Biological tests indicated that compounds 1, 4, 10, 12, 13, and 30 displayed significant anti-tomato spotted wilt virus (TSWV) activities compared with the positive control ningnanmycin. Moreover, compound 12 strongly inhibited the expression of the TSWV N, NSs, and NSm genes and TSWV NSs protein in plant host. Furthermore, compounds 4, 10, 12, 20, and 22 exhibited moderate insecticidal activities against TSWV thrip vector (Frankliniella occidentalis).
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