Bioactive Hydrogel Dressing with Inherent Antimicrobial and Antioxidant Activity for Wound Healing
文献类型： 外文期刊
作者： Gao, Zilong 1 ; Li, Xiang 1 ; Jiang, Yiqing 1 ; Lu, Beihui 1 ; Zhang, Guozheng 1 ; Huang, Wengong 3 ; Li, Yurong 1 ; Zhang, Yeshun 1 ;
作者机构： 1.Jiangsu Univ Sci & Technol, Sch Biotechnol, Jiangsu Key Lab Sericultural Biol & Biotechnol, Zhenjiang 212100, Jiangsu, Peoples R China
2.Chinese Acad Agr Sci, Sericultural Sci Res Ctr, Key Lab Silkworm & Mulberry Genet Improvement, Minist Agr & Rural Affairs, Zhenjiang 212100, Jiangsu, Peoples R China
3.Guangxi Sericulture Technol Promot Stn, Nanning 530007, Guangxi, Peoples R China
期刊名称：BIOMACROMOLECULES （ 影响因子：5.4； 五年影响因子：5.8 ）
ISSN： 1525-7797
年卷期： 2025 年 26 卷 9 期
页码：
收录情况： SCI
摘要： Bacterial infection and oxidative stress are major hindrances to wound healing. Designing bioactive wound dressings with inherent antibacterial and antioxidant activities is highly desirable. Herein, a novel multifunctional hydrogel was synthesized via a Schiff-base reaction between the amino groups of sericin and the aldehyde moieties of 2,3,4-trihydroxybenzaldehyde (THBA). The resulting hydrogel exhibited stable mechanical strength, exceptional tissue adhesiveness, and good biocompatibility, along with porous structures, a high swelling ratio, suitable gelation time, and adjustable degradability. In vitro experiments confirmed its inherent antibacterial and antioxidant capabilities, while in vivo studies using a full-thickness skin wound model in mice revealed accelerated wound healing and enhanced collagen deposition. These findings collectively underscore the potential of the sericin/THBA (SeT) hydrogel as an advanced dressing for effective wound management.
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