Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family
文献类型： 外文期刊
作者： Cui, Chao-Yue 1 ; Chen, Qiwei 4 ; He, Qian 1 ; Chen, Chong 1 ; Zhang, Rong-Min 1 ; Feng, Youjun 2 ; Sun, Jian 1 ;
作者机构： 1.South China Agr Univ, Coll Vet Med, Natl Risk Assessment Lab Antimicrobial Resistance, Guangzhou 510642, Guangdong, Peoples R China
2.South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou, Guangdong, Peoples R China
3.South China Agr Univ, Coll Vet Med, Guangdong Key Lab Vet Drug Dev & Safety Evaluat, Guangzhou, Guangdong, Peoples R China
4.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Lanzhou, Gansu, Peoples R China
5.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Microbiol, Hangzhou 310058, Zhejiang, Peoples R China
6.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gen Intens, Hangzhou 310058, Zhejiang, Peoples R China
7.Yangzhou Univ, Inst Agr Sci & Technol Dev, Minist Educ China, Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Jiangsu, Peoples R China
8.Zhejiang Univ, Coll Anim Sci, Hangzhou, Zhejiang, Peoples R China
关键词： Tet(X); tetracycline; tigecycline resistance; transferability
期刊名称：WIRES MECHANISMS OF DISEASE
ISSN： 2692-9368
年卷期：
页码：
收录情况： SCI
摘要： Tetracycline and its derivative tigecycline are clinical options against Gram-negative bacterial infections. The emergence of mobile Tet(X) enzymes that destruct tetracycline-type antibiotics is posing a big challenge to antibacterial therapy and food/environmental securities. Here, we present an update on a growing number of Tet(X) variants. We describe structure and action of Tet(X) enzyme, and discuss the evolutional origin. In addition, potential Tet(X) inhibitors are given. This mini-review might benefit better understanding of Tet(X)-mediated tigecycline resistance. This article is categorized under: Infectious Diseases > Genetics/Genomics/Epigenetics Infectious Diseases > Environmental Factors Infectious Diseases > Molecular and Cellular Physiology
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