Genomic and phylogeographical analysis revealed CTX-M-55 producing Escherichia coli ST10 and ST2325 clones of One Health concern from dairy farm waste in Gansu, China
文献类型： 外文期刊
作者： Shoaib, Muhammad 1 ; Ali, Muhammad Muddassir 3 ; Tang, Minjia 1 ; Wang, Weiwei 1 ; Zhang, Xuejing 1 ; He, Zhuolin 1 ; Wu, Zhongyong 1 ; Wang, Shengyi 1 ; Hao, Baocheng 1 ; Li, Ruichao 2 ; Pu, Wanxia 1 ;
作者机构： 1.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Key Lab New Anim Drug Project, Gansu Prov Key Lab Vet Pharmaceut Dev,Minist Agr &, Lanzhou 730050, Peoples R China
2.Yangzhou Univ, Coll Vet Med, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China
3.Univ Vet & Anim Sci, Inst Biochem & Biotechnol, Lahore 54000, Pakistan
关键词： Genomic surveillance; ESBL-producing E. coli; Resistome; Virulome; Mobilome; One Health clones
期刊名称：ONE HEALTH （ 影响因子：4.5； 五年影响因子：4.7 ）
ISSN：
年卷期： 2025 年 20 卷
页码：
收录情况： SCI
摘要： Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli resists broad-spectrum cephalosporins, considered as a critical priority pathogen, and its presence in animals, humans, and the environment highlights its significance as a One Health issue. Dairy farm waste is a potential environmental contaminant and can serves as a significant reservoir for the emergence and spread of ESBL-producing E. coli, which belongs to One Health clones and poses a serious global threat. This study aimed to investigate the occurrence and genomic characteristics of ESBL-producing E. coli clones of One Health concern from dairy farm waste in Gansu, China. In this study, we isolated and characterized two CTX-M-55 ESBL-producing E. coli strains, ZYX8158 and ZYS8091, which belong to One Health clones. The genomic analysis revealed a large resistome, mobilome, virulome, and plasmidome was acquired by both ESBL-producing E. coli strains. The genome-based typing revealed that E. coli ZYX8158 and ZYS8091 belonged to globally disseminated clones ST10 (O73:H31 serotype) and ST2325 (O66: H25 serotype), respectively. Phylogeographical analysis revealed both strains as potential One Health clones due to their clustering with related E. coli strains isolated from animal, human, and environmental sources, regardless of geographical boundaries, indicating their zoonotic potential and clonal spread in the One Health sector. This study highlights that dairy farm waste can be a potential source of the emergence and dissemination of One Health clones of critical priority ESBL-producing E. coli in One Health settings, which demands continuous and integrated genomic surveillance for comprehensive knowledge and mitigation strategies.
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