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Characterization of four novel H5N6 avian influenza viruses with the internal genes from H5N1 and H9N2 viruses and experimental challenge of chickens vaccinated with current commercially available H5 vaccines

文献类型： 外文期刊

作者： Peng, Chen 1 ; Zhao, Pengwei 2 ; Chu, Jun 1 ; Zhu, Junda 1 ; Li, Qiuchen 1 ; Zhao, Haiyuan 4 ; Li, Yujie 5 ; Xin, Lingxia 1 ;

作者机构： 1.China Agr Univ, Coll Vet Med, Beijing, Peoples R China

2.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Biochem, Hangzhou, Peoples R China

3.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Cardiol, Hangzhou, Peoples R China

4.JilinGuan Jie Biol Technol Co LTD, Changchun, Peoples R China

5.Shandong Prov Ctr Anim Dis Control, Jinan, Peoples R China

6.China Inst Vet Drug Control, Beijing 100081, Peoples R China

7.South China Agr Univ, Natl & Reg Joint Engn Lab Medicament Zoonoses Pre, Coll Vet Med, Guangzhou, Peoples R China

8.Chinese Acad Agr Sci, Beijing 100081, Peoples R China

关键词： efficacy; pathogenicity; phylogenetic analysis; protective

期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：5.005； 五年影响因子：4.622 ）

ISSN： 1865-1674

年卷期：

页码：

收录情况： SCI

摘要： Since 2014, highly pathogenic avian influenza H5N6 viruses have been responsible for outbreaks in poultry. In this study, four H5N6 virus strains were isolated from faecal samples of sick white ducks and dead chickens in Shandong in 2019. These H5N6 viruses were triple-reassortant viruses that have not been previously characterized. Their HA genes were derived from the H5 viruses and were closely related to the vaccine strain Re-11. Their NA genes all fell into the N6-like lineage and the internal gene were derived from H5N1 and H9N2 viruses. They all showed high pathogenicity in mice and caused lethal infection with high rates of transmission in chickens. Moreover, the SPF chickens inoculated with the currently used H5 (Re-11 and Re-12 strains)/H7 (H7-Re-2 strain) trivalent inactivated vaccines in China were completely protected from these four H5N6 viruses. Our study indicated the necessity of continued surveillance for H5 influenza A viruses and the importance of timely update of vaccine strains in poultry industry.

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