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Algal oil alleviates antibiotic-induced intestinal inflammation by regulating gut microbiota and repairing intestinal barrier

文献类型： 外文期刊

作者： Zhang, Huimin 1 ; Xu, Zhenxia 1 ; Chen, Wenchao 1 ; Huang, Fenghong 1 ; Chen, Shouwen 2 ; Wang, Xu 4 ; Yang, Chen 1 ;

作者机构： 1.Oil Crops Res Inst Chinese Acad Agr Sci, Oil Crops & Lipids Proc Technol Natl & Local Joint, Hubei Key Lab Lipid Chem & Nutr, Wuhan, Peoples R China

2.Hubei Univ, Environm Microbial Technol Ctr Hubei Prov, State Key Lab Biocatalysis & Enzyme Engn, Wuhan, Peoples R China

3.Shandong Acad Agr Sci, Inst Food & Nutr Sci & Technol, Jinan, Peoples R China

4.Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan, Peoples R China

关键词： algal oil; polyunsaturated fatty acids; intestinal barrier; intestinal inflammation; gut microbiota

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：5.0； 五年影响因子：5.7 ）

ISSN： 2296-861X

年卷期： 2023 年 9 卷

页码：

收录情况： SCI

摘要： IntroductionTaking antibiotics would interfere with gut microbiota and increase the risk of opportunistic pathogen infection and inflammation. MethodsIn this study, 36 male C57BL/6 mice were divided into 4 groups (n = 9) to investigate whether two kinds of algal oil could alleviate the intestinal damage induced by CS (Ceftriaxone sodium). These algal oils were obtained from Schizochytrium sp. cultures using Yeast extract (YE) and Rapeseed meal (RSM) as substrate, respectively. All tested mice were administrated with CS for 8 days and then the colon pathological morphology, the expression levels of inflammatory factors and the gut microbial profile were analyzed in mice supplemented with or without algal oil. ResultsThe results showed that both YE and RSM algal oils markedly reduced mucosal damage and intestinal inflammatory response in CS-treated mice by inhibiting the pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and myeloperoxidase (MPO) activity. In addition, fluorescence immunohistochemistry showed that the tight junction protein ZO-1 was increased in mice supplemented with YE and RSM algal oil. Furthermore, YE algal oil promoted the beneficial intestinal bacteria such as Lachnospiraceae and S24_7 compared with the CS group, while supplementation with RSM algal oil enriched the Robinsoniella. Spearman's correlation analysis exhibited that Melissococcus and Parabacteroides were positively correlated with IL-6 but negatively correlated with IL-10. DiscussionThis study suggested that supplementation with algal oil could alleviate intestinal inflammation by regulating gut microbiota and had a protective effect on maintaining intestinal barrier against antibiotic-induced damage in mice.

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