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Critical roles of non-coding RNAs in lifecycle and biology of Marek's disease herpesvirus

文献类型： 外文期刊

作者： Teng, Man 1 ; Zhu, Zhi-Jian 4 ; Yao, Yongxiu 5 ; Nair, Venugopal 5 ; Zhang, Gai-Ping 7 ; Luo, Jun 1 ;

作者机构： 1.Henan Acad Agr Sci, Key Lab Anim Immunol, Minist Agr & Rural Affairs China, Zhengzhou 450002, Peoples R China

2.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Zhengzhou 450002, Peoples R China

3.Henan Acad Agr Sci, UK China Ctr Excellence Res Avian Dis, Zhengzhou 450002, Peoples R China

4.Huanghuai Univ, Sch Biol & Food Proc Engn, Zhumadian 463000, Peoples R China

5.Pirbright Inst, Ash Rd, Guildford GU24 0NF, Surrey, England

6.UK China Ctr Excellence Res Avian Dis, Ash Rd, Guildford GU24 0NF, Surrey, England

7.Henan Agr Univ, Int Joint Res Ctr Natl Anim Immunol, Zhengzhou 450002, Peoples R China

8.Henan Agr Univ, Coll Vet Med, Zhengzhou 450002, Peoples R China

9.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China

10.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Key Lab Anim Dis & Publ Safety, Luoyang 471003, Peoples R China

关键词： herpesvirus; MDV; miRNA; lincRNA; circRNA; CRISPR; pathogenesis; oncogenesis

期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：9.1； 五年影响因子：7.1 ）

ISSN： 1674-7305

年卷期： 2023 年 66 卷 2 期

页码：

收录情况： SCI

摘要： Over the past two decades, numerous non-coding RNAs (ncRNAs) have been identified in different biological systems including virology, especially in large DNA viruses such as herpesviruses. As a representative oncogenic alphaherpesvirus, Marek's disease virus (MDV) causes an important immunosuppressive and rapid-onset neoplastic disease of poultry, namely Marek's disease (MD). Vaccinations can efficiently prevent the onset of MD lymphomas and other clinical disease, often heralded as the first successful example of vaccination-based control of cancer. MDV infection is also an excellent model for research into virally-induced tumorigenesis. Recently, great progress has been made in understanding the functions of ncRNAs in MD biology. Herein, we give a review of the discovery and identification of MDV-encoded viral miRNAs, focusing on the genomics, expression profiles, and emerging critical roles of MDV-1 miRNAs as oncogenic miRNAs (oncomiRs) or tumor suppressor genes involved in the induction of MD lymphomas. We also described the involvements of host cellular miRNAs, lincRNAs, and circRNAs participating in MDV life cycle, pathogenesis, and/or tumorigenesis. The prospects, strategies, and new techniques such as the CRISPR/Cas9-based gene editing applicable for further investigation into the ncRNA-mediated regulatory mechanisms in MDV pathogenesis/oncogenesis were also discussed, together with the possibilities of future studies on antiviral therapy and the development of new efficient MD vaccines.

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