Preparation and Comprehensive Evaluation of the Efficacy and Safety of Chlorantraniliprole Nanosuspension
文献类型： 外文期刊
作者： Ding, Xiquan 1 ; Guo, Liang 2 ; Du, Qian 1 ; Wang, Tingyu 1 ; Zeng, Zhanghua 1 ; Wang, Yan 1 ; Cui, Haixin 1 ; Gao, Fei 1 ; Cui, Bo 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Environm & Sustainable Dev Agr, Beijing 100081, Peoples R China
2.Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450046, Peoples R China
关键词： chlorantraniliprole; nanosuspension; efficacy; safety
期刊名称：TOXICS （ 影响因子：4.6； 五年影响因子：4.8 ）
ISSN：
年卷期： 2024 年 12 卷 1 期
页码：
收录情况： SCI
摘要： Chlorantraniliprole is a broad-spectrum insecticide that has been widely used to control pests in rice fields. Limited by its low solubility in both water and organic solvents, the development of highly efficient and environmentally friendly chlorantraniliprole formulations remains challenging. In this study, a low-cost and scalable wet media milling technique was successfully employed to prepare a chlorantraniliprole nanosuspension. The average particle size of the extremely stable nanosuspension was 56 nm. Compared to a commercial suspension concentrate (SC), the nanosuspension exhibited superior dispersibility, as well as superior foliar wetting and retention performances, which further enhanced its bioavailability against Cnaphalocrocis medinalis. The nanosuspension dosage could be reduced by about 40% while maintaining a comparable efficacy to that of the SC. In addition, the chlorantraniliprole nanosuspension showed lower residual properties, a lower toxicity to non-target zebrafish, and a smaller effect on rice quality, which is conducive to improving food safety and the ecological safety of pesticide formulations. In this work, a novel pesticide-reduction strategy is proposed, and theoretical and data-based support is provided for the efficient and safe application of nanopesticides.
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