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Evaluation of the combined toxicity of multi-walled carbon nanotubes and cadmium on earthworms in soil using multi-level biomarkers

文献类型： 外文期刊

作者： Yang, Xiaoxia 1 ; Gong, Jiuping 1 ; Zhang, Xuemei 1 ; Huang, Yongchuan 1 ; Zhang, Wei 1 ; Yang, Junying 1 ; Lin, Junji 1 ;

作者机构： 1.Chongqing Acad Agr Sci, Inst Agr Qual Std & Testing Technol, Chongqing 401329, Peoples R China

2.Chongqing Three Gorges Univ, Key Lab Water Environm Evolut & Pollut Control Th, Chongqing 404100, Peoples R China

关键词： Biomarker integration index; Concentration addition index; Cytochrome P450 isoenzymes; Effect addition index; Metabolomics; Toxic mode

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

ISSN： 0147-6513

年卷期： 2021 年 221 卷

页码：

收录情况： SCI

摘要： The coexistence of multi-walled carbon nanotubes (MWCNTs) with cadmium (Cd) in soil may cause the combined biological effects, but few study reported about their joint toxic effects on earthworms. Therefore, this study investigated the effects of sub-lethal levels of MWCNTs (10, 50, 100 mg/kg) and Cd (2.0, 10 mg/kg) on earthworms Eisenia fetida for 14 days. The changes in multi-level biomarkers of growth inhibition rate, cytochrome P450 isoenzymes (CYP1A2, 2C9 and 3A4), and small molecular metabolites (metabolomics) were determined. The toxic interaction between MWCNTs and Cd was characterized by the combination of the biomarker integration index (BRI), joint effect index concentration addition index (CAI), and the effect concentration addition index (EAI). The results showed that the single MWCNTs exposure caused insignificant change in most biomarkers, while the combined exposure of MWCNTs (50-100 mg/kg) and 10 mg/kg Cd led to significant changes in ten most important metabolites identified by metabolomics and activities of CYP1A2, 2C9, and 3A4. Compared with the toxicity of Cd alone, the combined toxicity of the mixture was significantly reduced. According to the integration of BRI and CAI/EAI, a clearly antagonistic interaction at relatively low effects was observed between MWCNTs and Cd. The responses of multiple biomarkers suggest the toxic action mode of the mixture on earthworms was related to the oxidative injury, and the disruption of amino acid, purine, and pyrimidine metabolism, and the urea cycle.

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