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Flavonoid-rich sesame leaf extract-mediated synthesis of nanozymes: Extraction optimization, chemical composition identification and bioactivity evaluation

文献类型： 外文期刊

作者： Zhang, Ruiying 1 ; Liu, Yufei 2 ; Gao, Yiqiao 2 ; Peng, Dengfeng 1 ; Luan, Qian 3 ; Li, Ziliang 1 ; Xia, Xiaoyang 1 ; Xiang, Xia 1 ;

作者机构： 1.Chinese Acad Agr Sci, Oil Crops & Lipids Proc Technol Natl & Local Joint, Key Lab Oilseeds Proc,Minist Agr & Rural Affairs, Hubei Key Lab Lipid Chem & Nutr,Oil Crops Res Inst, Wuhan 430062, Peoples R China

2.Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China

3.Zhejiang Univ, Ningbo Innovat Ctr, Ningbo 315100, Peoples R China

关键词： Sesame leaves; Flavonoid; Nanoparticles; Nanozymes; Biological activity

期刊名称：FOOD CHEMISTRY （ 影响因子：8.5； 五年影响因子：8.2 ）

ISSN： 0308-8146

年卷期： 2024 年 456 卷

页码：

收录情况： SCI

摘要： Sesame leaves contain rich phenolic acids and flavonoids. However, their potential in nanozyme synthesis has not been investigated yet. Herein, we report the preparation of flavonoid-rich sesame leaf extract (SLE), composition identification, and its use in the construction of iron (Fe)-based nanozymes (Fe-SLE CPNs). SLE was obtained with an extraction yield of -14.5% with a total flavonoid content (TFC) of -850.85 mg RE/g. There were 83 flavonoid compounds in SLE, primarily including scutellarin, apigenin-7-glucuronid, narcissin, and hyperoside. Fe-SLE CPNs exhibited nanodot morphology with a hydrodynamic size of 79.34 nm and good stability in various physiological solutions, pH levels, and temperatures. The Fe-SLE CPNs were more efficient in the scavenging ability of reactive oxygen species (ROS) than SLE alone. Furthermore, a stronger anti-inflammatory effect of the Fe-SLE CPNs was shown by modulating the MyD88-NF-kappa B-MAPK signaling pathways. These findings imply that SLE-based nanozymes hold great potential for diverse applications.

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