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Differential Retention and Loss of a Mycotoxin in Fungal Evolution

文献类型： 外文期刊

作者： Chen, Lin 1 ; Yan, Ziying 2 ; Yang, Bolei 2 ; Tai, Bowen 2 ; Li, Weizhao 2 ; Li, Erfeng 3 ; Wang, Gang 2 ; Xing, Fuguo 2 ;

作者机构： 1.Huanghe Sci & Technol Coll, Comprehens Utilizat Edible & Med Plant Resources E, Zhengzhou Key Lab Synthet Biol Nat Prod, Zhengzhou 450006, Peoples R China

2.Chinese Acad Agr Sci, Inst Food Sci & Technol, Key Lab Agroprod Qual & Safety Control Storage & T, Minist Agr & Rural Affairs, Beijing 100193, Peoples R China

3.Tianjin Agr Univ, Hort & Landscape Coll, Tianjin 300392, Peoples R China

关键词： ochratoxin; gene cluster; evolution; degeneration

期刊名称：TOXINS （ 影响因子：4.0； 五年影响因子：4.5 ）

ISSN：

年卷期： 2025 年 17 卷 6 期

页码：

收录情况： SCI

摘要： Ochratoxin A (OTA) is designated as a mycotoxin and is regulated worldwide due to its harmful effects on humans and animals, but the evolutionary history and ecological significance of OTA in fungi remain poorly understood. Phylogenetic analysis suggested that Aspergillus and Metarhizium obtained an ancient OT cluster, which evolved independently, followed by horizontal OT transfer from Aspergillus to Penicillium. The varying presence of functional, absent and pseudogenized OT genes across Aspergillus species revealed that this cluster is undergoing a degeneration process in this genus. Furthermore, the cyclase OtaY in the OTA cluster is likely derived from bacteria, which was revealed by phylogenetic analysis. This is the first attempt to investigate the ecological significance of OTA in fungi, suggesting that it may be nonfunctional in Aspergillus spp. and has undergone multiple forms of loss during evolution.

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