您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Antibacterial efficacy and pharmacokinetics of a poly(mPEG-b-PCEA)-trimethoprim conjugate

文献类型： 外文期刊

作者： Niu, Ming 1 ; Zhang, Zhenghua 2 ; Wang, Rourou 1 ; Zhou, Yaxin 3 ; Zhou, Jing 1 ; Pu, Lumei 1 ; Xu, Weibing 1 ;

作者机构： 1.Gansu Agr Univ, Coll Sci, Lanzhou 730000, Peoples R China

2.Lanzhou Resources & Environm Voc Tech Univ, Coll Environm & Chem Engn, Lanzhou 730022, Peoples R China

3.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730000, Peoples R China

期刊名称：NEW JOURNAL OF CHEMISTRY （ 影响因子：2.5； 五年影响因子：2.7 ）

ISSN： 1144-0546

年卷期： 2025 年 49 卷 28 期

页码：

收录情况： SCI

摘要： Research into antimicrobials is crucial for the sustainable development of the livestock industry. Trimethoprim (TMP) is one of the most widely used antimicrobial agents in the world. However, its efficacy is often limited by poor water solubility and dose-limiting properties. In this work, amphiphilic block polymer carriers are prepared using the oxygen-induced reversible addition-fragmentation chain transfer polymerization reaction. TMP is linked to carriers in different ratios to form poly(mPEG-b-PCEA)-TPM conjugates. The conjugates are characterized using various methods including H-1 NMR, FT-IR, XRD and SEM. The results of in vitro antimicrobial experiments show that poly(mPEG-b-PCEA)-TMP with different ratios has more prominent antimicrobial effects than the same dosage of pure TMP. poly(mPEG-b-PCEA)-TMP80 shows the most significant results, inhibiting E. coli by 87.19% and S. aureus by 97.02%, with a hemolysis rate of <5% and good biocompatibility. In vivo pharmacokinetics show an increase in C-max from 4.81 mu g mL(-1) to 6.57 mu g mL(-1) and AUC(0-48) from 78.55 h mu g mL(-1) to 89.11 h mu g mL(-1) for poly(mPEG-b-PCEA)-TMP80 compared to commercially available TMP tablets. This strategy can effectively improve the antibacterial activity and pharmacokinetics and increase the bioavailability of TMP.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台