文献类型： 外文期刊
作者： Han, Rongjia 1 ; Wang, Weiwei 1 ; Zhou, Yaxin 1 ; Li, Bing 1 ; Hu, Rongbin 1 ; Zuo, Jingru 1 ; Xing, Jiabao 4 ; Zhang, Hongxing 1 ; Huang, Huan 1 ; Bai, Yubin 1 ; Zhang, Jiyu 1 ;
作者机构： 1.Key Lab New Anim Drug Project Gansu Prov, Lanzhou 730050, Peoples R China
2.Minist Agr & Rural Affairs, Key Lab Vet Pharmaceut Dev, Lanzhou 730050, Peoples R China
3.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Peoples R China
4.Fudan Univ, Sch Publ Hlth, Key Lab Publ Hlth Safety, Minist Educ, Shanghai 200032, Peoples R China
关键词： Antibiotic resistance; Extracellular vesicles; Nano delivery systems; Targeted therapy; Clinical translation
期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：13.2； 五年影响因子：13.5 ）
ISSN： 1385-8947
年卷期： 2025 年 520 卷
页码：
收录情况： SCI
摘要： The escalating crisis of antimicrobial resistance (AMR) has underscored the imperative for innovative therapeutic strategies to combat multidrug-resistant (MDR) pathogens. Extracellular vesicles (EVs) have emerged as a revolutionary platform in antimicrobial therapy due to their intrinsic biocompatibility, precise targeting capabilities, and immunomodulatory functions. This review provides a comprehensive analysis of the origin, biogenesis, isolation, characterization techniques, and cutting-edge applications of EVs. We emphasize the integration of nanotechnology and EVs engineering strategies-such as antibiotic delivery, membrane coating, membrane fusion, and intelligent drug-loading technologies optimize vesicle targeting, stability, and controlled release, thereby achieving synergistic antimicrobial effects. Despite their promising potential in vaccine development and infection diagnostics, significant challenges remain in scalable production, heterogeneity control, pharmacokinetics, and clinical translation. Moreover, we propose multidisciplinary innovations, including EVs-antimicrobial combination, smart response therapies, personalized therapies, and digitalization and machine learning to expedite the transition of EVs from bench to bedside. By bridging bioengineering and nanotechnology, EVs hold the potential to redefine antimicrobial treatment paradigms, offering sustainable defense strategies for the post-antibiotic era.
- 相关文献
作者其他论文 更多>>
-
Bioremediation of complex organic pollutants by engineered Vibrio natriegens
作者：Su, Cong;Liu, Yong;Wang, Chen;Qu, Liwen;Dai, Junbiao;Cui, Haotian;Wang, Weiwei;Cheng, Zhenyu;Yang, Mengqiao;Li, Ye;He, Siyang;Xu, Ping;Tang, Hongzhi;Cui, Haotian;Wang, Weiwei;Cheng, Zhenyu;Yang, Mengqiao;Li, Ye;He, Siyang;Xu, Ping;Tang, Hongzhi;Cai, Yuejin;Zheng, Jiaxin;Zhao, Pingping;Dai, Junbiao
关键词：
-
Effects of Chicken Manure Combinations on Compost Maturity and Microbial Community Dynamics in Industrial-Scale Composting
作者：Wang, Weiwei;Zhang, Peng;He, Huiban;Liu, Hao;He, Haoxing;Cui, Zongjun;Yuan, Xufeng;Yuan, Xufeng;Wen, Boting;Yan, Jing
关键词：Aerobic composting; Chicken manure; Compost maturity; Microbial community
-
Integration of RPA and CRISPR-Cas13a collateral activity for one-step detection of DHAV-3: A biological macromolecule-enabled diagnostic platform
作者：Zhao, Saisai;Zhang, Jiahao;Yu, Shumin;He, Dalin;Fan, Yaru;Liu, Guocheng;Diao, Youxiang;Li, Bing;Tang, Yi
关键词：CRISRPR/Cas13; RPA-CRISPR Cas13a; Lateral flow assay; Duck hepatitis a virus 3
-
Infectious bursal disease virus affecting interferon regulatory factor 7 signaling through VP3 protein to facilitate viral replication
作者：Wang, Zhiyuan;Chen, Yang;Chen, Yanyan;Chen, Rui;Hu, Shichen;Li, Yihai;He, Xiumiao;Wang, Weiwei;Wei, Ping;Chen, Hongjun
关键词：infectious bursal disease virus (IBDV); interferon regulatory factor 7 (IRF7); antiviral response; IBDV VP3 protein; viral replication
-
Synergistic pathogenicity of novel duck Orthoreovirus and salmonella typhimurium in ducks
作者：Li, Bing;Mao, Mingtian;Li, Huihui;Wu, Mian;Lu, Chengguang;Lu, Meixi;Guo, Zhanbao;Liang, Suyun;Zhou, Zhengkui;Hou, Shuisheng;Tang, Yi;Man, Xinhong;Yuan, Mengdi;Diao, Youxiang
关键词：Novel Duck Orthoreovirus; Salmonella Typhimurium; Co-infection; Co-pathogenicity
-
Assessing oxytetracycline stress and antibiotic resistance gene dynamics during anaerobic treatment of cow manure
作者：He, Huiban;Chen, Xiaotian;Zhang, Peng;He, Haoxing;Wang, Weiwei;Cui, Zongjun;Yuan, Xufeng;Wen, Boting
关键词：Oxytetracycline; Antibiotic resistance genes; Anaerobic digestion; Biogas slurry storage; Slurry application
-
Prevalence and molecular characterization of cystic echinococcosis in livestock in the Hazara Division, Pakistan
作者：Arbab, Safia;Wang, Weiwei;Zhang, Jiya;Arbab, Safia;Wang, Weiwei;Zhang, Jiya;Arbab, Safia;Wang, Weiwei;Zhang, Jiya;Ullah, Hanif;Ul Hassan, Inam;Qadeer, Abdul
关键词：prevalence; echinococcosis; livestock; molecular characterization; Hazara Division;
Echinococcus granulosus
