Modulation of pectin on intestinal barrier function via changes in microbial functional potential and bile acid metabolism
文献类型： 外文期刊
作者： Yin, Chang 1 ; Wen, Xiaobin 1 ; Dang, Guoqi 1 ; Zhong, Ruqing 1 ; Meng, Qingshi 1 ; Feng, Xiaohui 1 ; Liu, Lei 1 ; Wu, Shusong 1 ; He, Jianhua 2 ; Chen, Liang 1 ; Zhang, Hongfu 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr & Feeding, Beijing, Peoples R China
2.Hunan Agr Univ, Coll Anim Sci, Changsha, Peoples R China
3.Chinese Acad Agr Sci, Inst Anim Sci, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China
关键词： pectin; ileal microbiota; bile acid; intestinal health.
期刊名称：JOURNAL OF NUTRITIONAL BIOCHEMISTRY （ 影响因子：5.6； 五年影响因子：5.9 ）
ISSN： 0955-2863
年卷期： 2024 年 124 卷
页码：
收录情况： SCI
摘要： Weaning is one of the major factors that cause stress and intestinal infection in infants and in young animals due to an immature intestine and not fully developed immune functions. Pectin (PEC), a prebiotic polysaccharide, has attracted considerable attention in intestinal epithelial signaling and function via modulation of the microbial community. A total of 16 weaned piglets (21-d-old) were randomly assigned into two groups: control group and PEC group. Supplementation of 5% pectin improved intestinal mucosal barrier function by modulating the composition of the bile acid pool in piglets. Specifically, piglets in PEC group had less serum D -lactate content and alkaline phosphatase activity. In the ileum, dietary pectin increased the number of crypt PAS/ABpositive goblet cells and the mRNA expressions of MUC2, ZO -1 , and Occludin. Piglets in PEC group displayed a decreased abundance of Enterococcus (2.71 vs. 65.92%), but the abundances of Lactobacillus (30.80 vs. 7.93%), Streptococcus (21.41 vs. 14.81%), and Clostridium_sensu_stricto_1 (28.34 vs. 0.01%) were increased. Elevated concentrations of bile acids especially hyocholic acid species (HCAs) including HCA , HDCA , and THDCA were also observed. Besides, correlation analysis revealed that dietary pectin supplementation may have beneficial effects through stimulation of the crosstalk between gut microbes and bile acid synthesis within the enterohepatic circulation. Thus, dietary pectin supplementation exhibited a further positive effect on the healthy growth and development of weaned piglets. These findings suggest pectin supplementation as the prebiotic is beneficial for gut health and improvement of weaned stress via regulating microbiota and bile acid metabolism. (c) 2023 Elsevier Inc. All rights reserved.
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