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Chemical constituents from the rhizomes of Gastrodia elata f. glauca and their potential neuroprotective effects

文献类型： 外文期刊

作者： Wang, Zhi-Wei 1 ; Li, Yun 1 ; Liu, Da-Hui 3 ; Mu, Yan 1 ; Dong, Hong-Jing 1 ; Zhou, Hong-Lei 2 ; Wang, Xiao 1 ;

作者机构： 1.Qilu Univ Technol, Shandong Acad Sci, Shandong Anal & Test Ctr, Shandong Key Lab TCM Qual Control Technol, 19 Keyuan St, Jinan 250014, Shandong, Peoples R China

2.Shandong Univ Tradit Chinese Med, Coll Pharm, 4655 Daxue Rd, Jinan 250355, Shandong, Peoples R China

3.Yunnan Acad Agr Sci, Inst Med Plants, 9 Xueyun Rd, Kunming 650231, Yunnan, Peoples R China

关键词： Gastrodia elata f. glauca; Neuroprotective effects; N-6-bis(4-Hydroxybenzyl) adenosine

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

ISSN： 1874-3900

年卷期： 2018 年 24 卷

页码：

收录情况： SCI

摘要： A phytochemical study on the rhizomes of Gastrodia elata f. glauca resulted in the isolation of three new parishin derivatives and one new adenosine derivative, together with six known compounds. Their structures were elucidated mainly by spectroscopic analysis and compared to published data. All these isolates were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and new compound 4 showed potent activity with an EC50 value of 12.0 mu M.

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