Genotyping and pathogenic characterization of canine distemper virus based on mutations in the hemagglutinin gene in Chinese domestic dogs
文献类型： 外文期刊
作者： Chen, M. 1 ; Xin, T. 2 ; Hou, S. 2 ; Lin, W. 2 ; Song, W. 3 ; Zhu, H. 1 ; Huang, K. 2 ; Jia, H. 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China
2.Nanjing Agr Univ, Coll Vet Med, 1 Weigang St, Nanjing 210095, Jiangsu, Peoples R China
3.Guan Zhong Anim Hosp, Chaoyang Rd, Beijing 100020, Peoples R China
关键词： canine distemper virus; hemagglutinin; phylogenetic analysis; animal infection
期刊名称：POLISH JOURNAL OF VETERINARY SCIENCES （ 影响因子：0.821； 五年影响因子：1.005 ）
ISSN： 1505-1773
年卷期： 2018 年 21 卷 3 期
页码：
收录情况： SCI
摘要： Canine distemper virus (CDV) infects wild and domestic Canidae worldwide. The hemagglutinin (H) gene has the highest genetic variation in the genome of this virus. Thus, the H. gene is commonly used for lineage identification and genetic analyses. In order to study the genetic characteristics and pathogenicity of CDV strains prevalent in China, 132 samples were collected from domestic dogs with suspected CDV infection, 58 samples were confirmed to be positive, and the I i gene was successfully amplified from 15 samples. The epidemic strain was identified as type Asia-1 and the novel mutations, A51T, V58I, R179K and D262N, were detected in this strain. Isolated strains, BJ16B53, BJ16B14, and BJ17B8, were used for an animal infection experiment in raccoon dogs. BJ16B53 and BJ16B14 were found to cause clinical symptoms, death, and extensive lesions in various organs. These results are expected to facilitate the development of effective strategies to monitor and control CDV infection in China.
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