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Modeling bacterial interactions uncovers the importance of outliers in the coastal lignin-degrading consortium

文献类型： 外文期刊

作者： Peng, Qiannan 1 ; Zhao, Cheng 2 ; Wang, Xiaopeng 3 ; Cheng, Kelin 2 ; Wang, Congcong 2 ; Xu, Xihui 4 ; Lin, Lu 1 ;

作者机构： 1.Shandong Univ, Inst Marine Sci & Technol, Qingdao, Peoples R China

2.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr,Shenzhen Branch, Key Lab Synthet Biol,Minist Agr & Rural Affairs, Shenzhen, Peoples R China

3.Ningbo Univ, Chinese Minist Educ, Key Lab Aquacultral Biotechnol, Ningbo 315000, Peoples R China

4.Nanjing Agr Univ, Coll Life Sci, Dept Microbiol,Minist Agr & Rural Affairs, Key Lab Agr & Environm Microbiol, Nanjing, Peoples R China

5.Shandong Univ, Qingdao Key Lab Ocean Carbon Sequestrat & Negat Te, Qingdao, Peoples R China

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

ISSN：

年卷期： 2025 年 16 卷 1 期

页码：

收录情况： SCI

摘要： Lignin, as the abundant carbon polymer, is essential for carbon cycle and biorefinery. Microorganisms interact to form communities for lignin biodegradation, yet it is a challenge to understand such complex interactions. Here, we develop a coastal lignin-degrading bacterial consortium (LD), through "top-down" enrichment. Sequencing and physiological analyses reveal that LD is dominated by the lignin degrader Pluralibacter gergoviae (>98%), with additional rare non-degraders. Interestingly, LD, cultured in lignin-MB medium, significantly enhances cell growth and lignin degradation as compared to P. gergoviae alone, implying a role of additional outliers. Using genome-scale metabolic models, metabolic profiling and culture experiments, modeling of inter-species interactions between P. gergoviae, Vibrio alginolyticus, Aeromonas hydrophila and Shewanella putrefaciens, unravels cross-feeding of amino acids, organic acids and alcohols between the degrader and non-degraders. Furthermore, the sub-population ratio is essential to enforce the synergy. Our study highlights the unrecognized role of outliers in lignin degradation.

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