WD40-protein-mediated crosstalk among three epigenetic marks regulates chromatin states and yield in rice
文献类型： 外文期刊
作者： Yang, Liwen 1 ; Li, Dongwei 1 ; Guo, Weijun 1 ; Song, Juqi 1 ; Liu, Chaofan 1 ; Liu, Hanlin 1 ; Li, Cong 1 ; Gu, Xiaofeng 1 ;
作者机构： 1.Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing 100081, Peoples R China
关键词： DRW1; recruiter; epigenetic crosstalk; chromatin accessibility; grain yield
期刊名称：MOLECULAR PLANT （ 影响因子：24.1； 五年影响因子：25.8 ）
ISSN： 1674-2052
年卷期： 2025 年 18 卷 7 期
页码：
收录情况： SCI
摘要： Although there is increasing understanding of the regulatory effects of particular epigenetic marks, much less is known about how crosstalk among multiple marks affects genetic regulation. Here, we show that Dwarf-related WD40 protein 1 (DRW1) is involved in DNA 6mA demethylation, H3K27 trimethylation, and (OsALKBH1), the histone methyltransferase CURLY LEAF (OsCLF), and NOP2/Sun RNA methyltransferase family member 2 (OsNSUN2). Knockout of DRW1 significantly reduces the extent of chromatin occupancy by OsALKBH1, OsCLF, and OsNSUN2, resulting in increased chromatin accessibility and enhanced expression of genes associated with brassinosteroid biosynthesis and signaling. Gene editing at a CAAT-box (ATTGG-ATTGA) and a GATA motif (GATAGGG-GAT) in the DRW1 promoter leads to elevated DRW1 transcription and thereby enhanced rice grain yield and salt tolerance. In field trials, DRW1-overexpressing rice lines displayed yield increases of similar to 30.2% (in both normal and saline soils), accompanied by decreases in DNA 6mA and increases in H3K27me3 and RNA m5C levels at target genes. Overall, our study uncovers DRW1-mediated crosstalk among three epigenetic marks (DNA 6mA, H3K27me3, and RNA m5C) and reveals how this crosstalk controls transcriptional and post-transcriptional regulation to affect rice yield and salt tolerance.
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