Aqueous extract of Sanghuangporus baumii induces autophagy to inhibit cervical carcinoma growth
文献类型： 外文期刊
作者： Wu, Di 1 ; Yuan, Xuemei 2 ; Zhou, Ruijie 2 ; Chen, Wanchao 1 ; Li, Wen 1 ; Li, Zhengpeng 1 ; Li, Xueyin 2 ; Zhu, Rui 3 ; Wang, Hualin 2 ; Yang, Yan 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Natl Engn Res Ctr Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South,Mi, Shanghai 201403, Peoples R China
2.Wuhan Polytech Univ, Sch Life Sci & Technol, Wuhan, Peoples R China
3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Integrated Chinese & Western Med, Wuhan, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：6.1； 五年影响因子：6.5 ）
ISSN： 2042-6496
年卷期： 2023 年 14 卷 5 期
页码：
收录情况： SCI
摘要： Sanghuangporus baumii, an edible fungus rich in heteropolysaccharides, has been found to have some anti-cervical cancer effects. In the current study, the effects of an aqueous extract of S. baumii on cervical cancer were investigated in a U14 cervical carcinoma cell implanted female Kunming mouse model. An aqueous extract of S. baumii (SHWE) was administered to tumor-bearing mice by gavage for 21 days. SHWE treatment significantly inhibited tumor growth by 67.4% at a dose of 400 mg per kg bodyweight. Transcriptomic results showed that the expression of key genes GABARAP, VMP1, VAMP8 and STX17 which are involved in the autophagy pathway was regulated after SHWE treatment, suggesting that SHWE may induce autophagy in tumors. The results were further confirmed by measuring the LC3II/LC3I ratio using western blotting. Moreover, some differentially expressed genes were involved in the insulin signaling pathway, implying that SHWE induced autophagy by disturbing glucose uptake and utilization in tumors. The analysis of the gut microbiota indicated that SHWE treatment stimulated the proliferation of Akkermansia, a well-known probiotic that presented benefits in metabolic regulation and cancer therapy. In conclusion, SHWE administration modified the gut microbiota, disturbed the glucose metabolism and induced autophagy in tumors, and then inhibited the development of cervical carcinoma in vivo.
- 相关文献
作者其他论文 更多>>
-
A screening strategy for identifying umami peptides with multiple bioactivities from Stropharia rugosoannulata using in silico approaches and SPR sensing
作者：Li, Jialin;Li, Wen;Wu, Di;Zhang, Zhong;Chen, Wanchao;Yang, Yan;Li, Jialin;Liu, Xiaofeng;Chen, Wanchao
关键词：Umami peptide; Stropharia rugosoannulata; ACE; DPP-IV; Molecular docking; SPR
-
Lysine and threonine supplementation promotes postharvest quality of Volvariella volvacea mushroom during low-temperature preservation via maintenance of the citrate cycle
作者：Zheng, Tingting;Wang, Ying;Li, Zhengpeng;Bao, Dapeng;Tan, Qi;Zou, Gen;Su, Erzheng;Zhang, Jianguo;Li, Nanyi;Wei, Yongjun;Bao, Dapeng
关键词：Volvariella volvacea; Energy metabolism; Functional food; L -lysine; L -threonine
-
Anti-inflammatory Activity of Polysaccharide from Spent Substrate of Lentinula Edode Based on Extraction of High Pressure-Complex Enzyme
作者：Zhang, Zhong;Yan, Mengqiu;Li, Wen;Chen, Wanchao;Liu, Yanfang;Wu, Di;Zhou, Shuai;Zhang, Jingsong;Yang, Yan
关键词：Polysaccharide; Lentinula Edode; Spent Substrate; Anti-inflammatory Activity; High pressure-complex Enzyme
-
Effects of continuous enzymolysis on the umami characteristics of Lentinula edodes and the flavor formation mechanism of umami peptides
作者：Chen, Daoyou;Chen, Wanchao;Li, Wen;Wen, Xinmeng;Wu, Di;Zhang, Zhong;Yang, Yan;Chen, Daoyou
关键词：Lentinula edodes; Water extracts and continuous enzymolysis; NMR; LC-MS; Taste characterization; Umami peptide
-
Multiple Fingerprint-Activity Relationship Assessment of Immunomodulatory Polysaccharides from Ganoderma lucidum Based on Chemometric Methods
作者：Liu, Jing;Zhang, Jingsong;Feng, Jie;Tang, Chuanhong;Yan, Mengqiu;Zhou, Shuai;Chen, Wanchao;Wang, Wenhan;Liu, Yanfang;Liu, Jing
关键词：Ganoderma lucidum polysaccharides; immune activity; regression analysis; fingerprint-activity relationship
-
Structural elucidation and anti-inflammatory activity of a proteoglycan from spent substrate of Lentinula edodes
作者：Zhang, Zhong;Wu, Di;Li, Wen;Chen, Wanchao;Liu, Yanfang;Zhang, Jingsong;Wan, Jianing;Yu, Hailong;Zhou, Shuai;Yang, Yan
关键词：Proteoglycan; Lentinula edodes; Spent substrate; Structural characterization; Anti-inflammatory activity
-
Transcriptome Analysis Reveals the Putative Polyketide Synthase Gene Involved in Hispidin Biosynthesis in Sanghuangporus sanghuang
作者：Wei, Jiansheng;Wei, Jiansheng;Yuan, Xiaolong;Wang, Dong;Wang, Xinyue;Bi, Wei;Wang, Yi;Liu, Liangyan;Wang, Xinyue;Wang, Xinyue;Yang, Yan
关键词：Sanghuangporus sanghuang; transcriptome; hispidin biosynthesis; polyketide synthase; qRT-PCR
