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Structural elucidation and anti-inflammatory activity of a proteoglycan from spent substrate of Lentinula edodes

文献类型： 外文期刊

作者： Zhang, Zhong 1 ; Wu, Di 1 ; Li, Wen 1 ; Chen, Wanchao 1 ; Liu, Yanfang 1 ; Zhang, Jingsong 1 ; Wan, Jianing 1 ; Yu, Hailong 1 ; Zhou, Shuai 1 ; Yang, Yan 1 ;

作者机构： 1.Minist Agr, Natl Engn Res Ctr Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South, Inst Edible Fungi,Shanghai Acad Agr Sci, Shanghai 201403, Peoples R China

关键词： Proteoglycan; Lentinula edodes; Spent substrate; Structural characterization; Anti-inflammatory activity

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2023 年 224 卷

页码：

收录情况： SCI

摘要： A proteoglycan LEPS1 was firstly isolated and purified from the spent substrate of Lentinula edodes, an agricul-tural waste that may cause environmental pollution. The average molecular weight of LEPS1 was 1.18 x 104 g/ mol, and carbohydrate moiety (88.9 %) was composed of glucose, arabinose, galactose, xylose and mannose at a molar ratio of 1.2:1.2:1.0:2.3:1.1. The protein moiety (8.5 %) of LEPS1 was bonded to the polysaccharide chain via O-glycosidic linkage. LEPS1 could significantly improve the inflammatory injury of LPS stimulated RAW264.7 macrophages by inhibiting the secretion of NO and decreasing the levels of pro-inflammatory factors (TNF-alpha, IL-1 beta and IL-6). LEPS1 inhibited JAK-STAT1 and p38 MAPK signaling pathway via modulating JAK expression, phosphorylation of STAT1 and phosphorylation of p38, respectively. Moreover, LEPS1 could promote the expression of CD 206 and IL-10 which were the markers for repairing macrophages. Overall, LEPS1 had anti-inflammatory activity and can potentially treat as a novel anti-inflammation agent. This work could provide scientific basis and valuable information for the highly efficient utilization of spent L. edodes substrates as the by-product in mushroom industries.

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