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Glucose restriction enhances oxidative fiber formation: A multi-omic signal network involving AMPK and CaMK2

文献类型： 外文期刊

作者： Zhang, Kaiyi 1 ; Xie, Ning 1 ; Ye, Huaqiong 1 ; Miao, Jiakun 1 ; Xia, Boce 1 ; Yang, Yu 1 ; Peng, Huanqi 1 ; Xu, Shuang 1 ; Wu, Tianwen 1 ; Tao, Cong 1 ; Ruan, Jinxue 1 ; Wang, Yanfang 1 ; Yang, Shulin 1 ;

作者机构： 1.Chinese Acad Agr Sci CAAS, Inst Anim Sci, State Key Lab Anim Biotech Breeding, Beijing 100193, Peoples R China

2.Univ Liege, TERRA Teaching & Res Ctr, Precis Livestock & Nutr Unit, Gembloux Agrobio Tech, B-5030 Gembloux, Belgium

3.Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China

4.Huazhong Agr Univ, Key Lab Swine Genet & Breeding, Minist Agr & Rural Affairs, Wuhan, Peoples R China

期刊名称：ISCIENCE （ 影响因子：5.8； 五年影响因子：5.8 ）

ISSN：

年卷期： 2024 年 27 卷 1 期

页码：

收录情况： SCI

摘要： Skeletal muscle is a highly plastic organ that adapts to different metabolic states or functional demands. This study explored the impact of permanent glucose restriction (GR) on skeletal muscle composition and metabolism. Using Glut4(m) mice with defective glucose transporter 4, we conducted multi-omics analyses at different ages and after low-intensity treadmill training. The oxidative fibers were significantly increased in Glut4(m) muscles. Mechanistically, GR activated AMPK pathway, promoting mitochondrial function and beneficial myokine expression, and facilitated slow fiber formation via CaMK2 pathway. Phosphorylation-activated Perm1 may synergize AMPK and CaMK2 signaling. Besides, MAPK and CDK kinases were also implicated in skeletal muscle protein phosphorylation during GR response. This study provides a comprehensive signaling network demonstrating how GR influences muscle fiber types and metabolic patterns. These insights offer valuable data for understanding oxidative fiber formation mechanisms and identifying clinical targets for metabolic diseases.

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