The A2 haplotype of Echinococcus multilocularis is the predominant variant infecting humans and dogs in Yili Prefecture, Xinjiang
文献类型： 外文期刊
作者： Guo, Baoping 1 ; Cairen 1 ; Wu, Jianyong 2 ; Wang, Wenli 3 ; Wang, Bingjie 4 ; Ren, Yuan 1 ; Aizezi, Mayire 5 ; Mi, Rongsheng 6 ; Zhao, Li 5 ; Wen, Hao 1 ;
作者机构： 1.Xinjiang Med Univ, Affiliated Hosp 1, Clin Med Inst, State Key Lab Pathogenesis Prevent & Treatment Hi, 137 Liyushan Rd, Urumqi 830054, Xinjiang, Peoples R China
2.Xinjiang Med Univ, Sch Publ Hlth, 567 Shangde Rd North, Urumqi 830017, Xinjiang, Peoples R China
3.Anim Dis Prevent & Control Ctr Gansu Prov, 41 Hongliutan Rd, Lanzhou 730046, Peoples R China
4.Xinjiang Acad Anim Sci, Vet Res Inst, 726 Dongrong St, Urumqi 830000, Xinjiang, Peoples R China
5.Xinjiang Agr Univ, Coll Vet Med, Urumqi 830052, Xinjiang, Peoples R China
6.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Key Lab Anim Parasitol, Minist Agr,Lab Qual Safety Risk Assessment Anim P, Shanghai 200241, Peoples R China
关键词： Alveolar echinococcosis; Echinococcus multilocularis; Yili prefecture; Mitochondrial; Haplotypes; Pairwise fixation index; Variant
期刊名称：INFECTION GENETICS AND EVOLUTION （ 影响因子：3.2； 五年影响因子：3.0 ）
ISSN： 1567-1348
年卷期： 2024 年 119 卷
页码：
收录情况： SCI
摘要： Alveolar echinococcosis (AE), caused by Echinococcus multilocularis, is an important zoonotic disease. Yili Prefecture in Xinjiang is endemic for AE, however the molecular variability of E. multilocularis in this region is poorly understood. In this study, 127 samples were used for haplotypes analysis, including 79 tissues from humans, 43 liver tissues from small rodents, and 5 fecal samples from dogs. Genetic variability in E. multilocularis was studied using complete sequences of the mitochondrial (mt) genes of cytochrome b (cob), NADH dehydrogenase subunit 2 (nad2), and cytochrome c oxidase subunit 1 (cox1), using a total of 3558 bp per sample. The Asia haplotype 2 (A2) was the dominant haplotype, with 72.15% (57/79) prevalence in humans, 2.33% (1/43) in small rodents, and 80.00% (4/5) in dogs, followed by A5, the second most common haplotype, which infected 27.91% (12/43) small rodents. Haplotype network analysis showed that all haplotypes clustered together with the Asian group. Pairwise fixation index (FST) values showed lower level of genetic differentiation between different regions within the country. Compared with the sequences of E. multilocularis from North America and Europe, all concatenated sequences isolated from Yili Prefecture were highly differentiated and formed a single population. The A2 haplotype, analyzed using the cob, nad2, and cox1 genes of E. multilocularis, is the predominant variant in humans and dogs in Yili Prefecture.
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