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Metabolomics should be deployed in the identification and characterization of gene-edited crops

文献类型： 外文期刊

作者： Fraser, Paul D. 1 ; Aharoni, Asaph 2 ; Hall, Robert D. 3 ; Huang, Sanwen 6 ; Giovannoni, James J. 8 ; Sonnewald, Uw 1 ;

作者机构： 1.Royal Holloway Univ London, Sch Biol Sci, Egham Hill, Egham TW20 0EX, Surrey, England

2.Weizmann Inst Sci, Dept Plant & Environm Sci, Rehovot, Israel

3.Wageningen Univ & Res, Wageningen Res, Droevendaalsesteeg 1, Wageningen, Netherlands

4.Wageningen Univ & Res, Lab Plant Physiol, Droevendaalsesteeg 1, Wageningen, Netherlands

5.Netherlands Metab Ctr, Einsteinweg 55, Leiden, Netherlands

6.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Minist Agr, Genome Anal Lab, Shenzhen 518124, Peoples R China

7.Chinese Acad Agr Sci, Key Lab Biol & Genet Improvement Hort Crops, Minist Agr, Sino Dutch Joint Lab Hort Genom,Inst Vegetables &, Beijing 100084, Peoples R China

8.Cornell Univ, USDA ARS, Robert W Holley Ctr, Ithaca, NY 14853 USA

9.Cornell Univ, Boyce Thompson Inst Plant Res, Tower Rd, Ithaca, NY 14853 USA

10.Friedrich Alexander Univ Erlangen Nuremberg, Dept Biol, Erlangen, Germany

11.Max Planck Inst Mol Plant Physiol, Muhlenberg 1, D-14476 Potsdam, Germany

关键词： genome-editing; metabolomics; crop regulation; food system; substantial equivalence

期刊名称：PLANT JOURNAL （ 影响因子：6.417； 五年影响因子：7.627 ）

ISSN： 0960-7412

年卷期：

页码：

收录情况： SCI

摘要： Gene-editing techniques are currently revolutionizing biology, allowing far greater precision than previous mutagenic and transgenic approaches. They are becoming applicable to a wide range of plant species and biological processes. Gene editing can rapidly improve a range of crop traits, including disease resistance, abiotic stress tolerance, yield, nutritional quality and additional consumer traits. Unlike transgenic approaches, however, it is not facile to forensically detect gene-editing events at the molecular level, as no foreign DNA exists in the elite line. These limitations in molecular detection approaches are likely to focus more attention on the products generated from the technology than on the process in itself. Rapid advances in sequencing and genome assembly increasingly facilitate genome sequencing as a means of characterizing new varieties generated by gene-editing techniques. Nevertheless, subtle edits such as single base changes or small deletions may be difficult to distinguish from normal variation within a genotype. Given these emerging scenarios, downstream 'omics' technologies reflective of edited affects, such as metabolomics, need to be used in a more prominent manner to fully assess compositional changes in novel foodstuffs. To achieve this goal, metabolomics or 'non-targeted metabolite analysis' needs to make significant advances to deliver greater representation across the metabolome. With the emergence of new edited crop varieties, we advocate: (i) concerted efforts in the advancement of 'omics' technologies, such as metabolomics, and (ii) an effort to redress the use of the technology in the regulatory assessment for metabolically engineered biotech crops.

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