文献类型： 外文期刊

作者： Jahan, Tanzim ¹ ; Huda, Md. Nurul ¹ ; Zhang, Kaixuan ¹ ; He, Yuqi ¹ ; Lai, Dili ¹ ; Dhami, Namraj ² ; Quinet, Muriel ³ ; Ali, Md. Arfan ⁴ ; Kreft, Ivan ⁵ ; Woo, Sun-Hee ⁶ ; Georgiev, Milen I. ⁷ ; Fernie, Alisdair R. ⁸ ; Zhou, Meiliang ¹ ;

作者机构： 1.Chinese Acad Agr Sci, State Key Lab Crop Gene Resources & Breeding, Inst Crop Sci,Minist Agr & Rural Affairs, Key Lab Grain Crop Genet Resources Evaluat & Utili, Beijing 100081, Peoples R China

2.Pokhara Univ, Fac Hlth Sci, Sch Hlth & Allied Sci, Pokhara 30, Kaski, Nepal

3.Catholic Univ Louvain, Earth & Life Inst Agron ELI A, Grp Rech Physiol Vegetale GRPV, Croix Sud 45,Boite L7 07-13, B-1348 Louvain La Neuve, Belgium

4.Sher e Bangla Agr Univ, Fac Agr, Dept Hort, Dhaka 1207, Bangladesh

5.Nutr Inst, Koprska Ul 98, SI-1000 Ljubljana, Slovenia

6.Chungbuk Natl Univ, Dept Crop Sci, Cheongju, South Korea

7.Bulgarian Acad Sci, Inst Microbiol, Dept Biotechnol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria

8.Ctr Plant Syst Biol & Biotechnol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria

9.Max Planck Inst Mol Plant Physiol, Dept Mol Physiol, D-14476 Potsdam, Germany

关键词： Secondary metabolite; Biotic stress; Transcription factor; Metabolic engineering; CRISPR/Cas9; RNAi

期刊名称：BIOTECHNOLOGY ADVANCES （ 影响因子：12.5； 五年影响因子：15.7 ）

ISSN： 0734-9750

年卷期： 2025 年 79 卷

页码：

收录情况： SCI

摘要： Sustainable agriculture practices are indispensable for achieving a hunger-free world, especially as the global population continues to expand. Biotic stresses, such as pathogens, insects, and pests, severely threaten global food security and crop productivity. Traditional chemical pesticides, while effective, can lead to environmental degradation and increase pest resistance over time. Plant-derived natural products such as secondary metabolites like alkaloids, terpenoids, phenolics, and phytoalexins offer promising alternatives due to their ability to enhance plant immunity and inhibit pest activity. Recent advances in molecular biology and biotechnology have improved our understanding of how these natural compounds function at the cellular level, activating specific plant defense through complex biochemical pathways regulated by various transcription factors (TFs) such as MYB, WRKY, bHLH, bZIP, NAC, and AP2/ERF. Advancements in multi-omics approaches, including genomics, transcriptomics, proteomics, and metabolomics, have significantly improved the understanding of the regulatory networks that govern PSM synthesis. These integrative approaches have led to the discovery of novel insights into plant responses to biotic stresses, identifying key regulatory genes and pathways involved in plant defense. Advanced technologies like CRISPR/Cas9-mediated gene editing allow precise manipulation of PSM pathways, further enhancing plant resistance. Understanding the complex interaction between PSMs, TFs, and biotic stress responses not only advances our knowledge of plant biology but also provides feasible strategies for developing crops with improved resistance to pests and diseases, contributing to sustainable agriculture and food security. This review emphasizes the crucial role of PSMs, their biosynthetic pathways, the regulatory influence of TFs, and their potential applications in enhancing plant defense and sustainability. It also highlights the astounding potential of multi-omics approaches to discover gene functions and the metabolic engineering of genes associated with secondary metabolite biosynthesis. Taken together, this review provides new insights into research opportunities for enhancing biotic stress tolerance in crops through utilizing plant secondary metabolites.