Identification of miR-71*as a regulator of Flotillin-1 in egg development of Rhipicephalus sanguineus
文献类型： 外文期刊
作者： Wang, Qilin 1 ; Li, Muxiao 2 ; Liu, Wenge 1 ; Wang, Yanlong 1 ; Chen, Zeyu 1 ; Zhang, Zhenjie 2 ; Liu, Guangyuan 1 ; Qi, Meng 2 ;
作者机构： 1.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Lanzhou 730046, Gansu, Peoples R China
2.Tarim Univ, Coll Anim Sci & Technolody, Alar 843300, Xinjiang, Peoples R China
关键词：
期刊名称：VETERINARY RESEARCH COMMUNICATIONS （ 影响因子：2.0； 五年影响因子：2.1 ）
ISSN： 0165-7380
年卷期： 2025 年 49 卷 3 期
页码：
收录情况： SCI
摘要： Identifying the microRNAs (miRNAs) that regulate the growth and development of Rhipicephalus sanguineus (Rh. sanguineus) is essential for developing effective control strategies against both the tick and tick-borne pathogens. This study reveals the antagonistic regulatory mechanism between miR-71* (the passenger strand of miRNA-71) and Flotillin-1 in the egg development of Rh. sanguineus. Through bioinformatics prediction and validation using a dual-luciferase reporter system, we demonstrate for the first time that miR-71* directly targets and regulates Flotillin-1. Functional experiments indicate that inhibiting miR-71* significantly increases tick egg weight, while suppressing Flotillin-1 reduces egg weight, thereby suggesting that these molecules negatively regulate egg developmental processes. This discovery provides a novel target for elucidating reproductive regulatory pathways in ticks and lays a theoretical foundation for developing control strategies against ticks and tick-borne pathogens.
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