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Viral proteins suppress rice defenses by boosting OsTSN1 RNA decay via phase separation and multimerization

文献类型： 外文期刊

作者： Zeng, Ming 1 ; Fu, Shuai 1 ; Xu, Youping 3 ; Li, Liyan 1 ; Wang, Dan 1 ; Gao, Shi-bo 1 ; Zheng, Lianshun 1 ; Zhang, Yunge 1 ; Zhang, Cui 1 ; Fei, Shifang 1 ; Ye, Xuan 1 ; Chen, Lele 1 ; Wang, Yaqin 1 ; Zhang, Tong 5 ; Zhou, Xueping 1 ; Wu, Jianxiang 1 ;

作者机构： 1.Zhejiang Univ, Inst Biotechnol, State Key Lab Rice Biol & Breeding, Zhejiang Key Lab Biol & Ecol Regulat Crop Pathogen, Hangzhou, Zhejiang, Peoples R China

2.Zhejiang Lab, Res Ctr Life Sci Comp, Hangzhou, Peoples R China

3.Zhejiang Univ, Anal Ctr Agrobiol & Environm Sci, Hangzhou, Zhejiang, Peoples R China

4.Zhejiang Univ, Hainan Inst, Sanya, Peoples R China

5.South China Agr Univ, Coll Plant Protect, Guangdong Prov Key Lab Microbial Signals & Dis Con, Guangzhou, Peoples R China

6.Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing, Peoples R China

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

ISSN：

年卷期： 2025 年 16 卷 1 期

页码：

收录情况： SCI

摘要： Liquid-liquid phase separation (LLPS) forms membraneless condensates crucial for plant stress responses. However, how plant viruses utilize LLPS to escape host immunity remains largely unexplored. Here, we show that P6 protein encoded by southern rice black-streaked dwarf virus (SRBSDV) undergoes LLPS. P6 interacts with OsTSN1 to form the P6-OsTSN1-containing droplets co-localized with stress granules (SGs). Within these droplets, P6 enhances OsTSN1 nuclease activity via promoting its multimerization to degrade transcripts with G-A-rich motifs of two transcription factors (TFs), OsNAC15 and OsLHY. These two TFs regulate the transcription of OsJAZ6, OsJAZ12, and OsATG8C, key components of jasmonic acid (JA)- and autophagy-associated defense pathways. Furthermore, the degradation of OsNAC15 and OsLHY transcripts in P6-OsTSN1-containing droplets weakens JA- and autophagy-mediated defenses in rice, facilitating SRBSDV infection. Additionally, similar to SRBSDV P6, intrinsically disordered region (IDR)-containing RNA silencing suppressors encoded by rice black-streaked dwarf virus and rice stripe virus, also interact with OsTSN1, promoting the degradation of OsNAC15 and OsLHY transcripts to enhance viral infection. Our findings indicate that OsTSN1 acts as a central positive regulator of virus infection in rice, convergently co-opted by viruses. These insights help us to better understand the roles of LLPS and OsTSN1 in virus infection in rice.

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