Genome-wide association studies demonstrate that TASP1 contributes to increased muscle fiber diameter
文献类型： 外文期刊
作者： Liu, Dapeng 1 ; Fan, Wenlei 4 ; Xu, Yaxi 1 ; Yu, Simeng 1 ; Liu, Wenjing 1 ; Guo, Zhanbao 1 ; Huang, Wei 1 ; Zhou, Zhengk 1 ;
作者机构： 1.Chinese Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Anim Poultry Genet Breeding & Reprod, Beijing, Peoples R China
2.Chinese Acad Agr Sci, State Key Lab Anim Nutr, Beijing, Peoples R China
3.Chinese Acad Agr Sci, Inst Anim Sci, Beijing, Peoples R China
4.Qingdao Agr Univ, Coll Food Sci & Engn, Qingdao, Peoples R China
5.Qingdao Agr Univ, Coll Anim Sci, Qingdao, Peoples R China
期刊名称：HEREDITY （ 影响因子：3.436； 五年影响因子：4.101 ）
ISSN： 0018-067X
年卷期：
页码：
收录情况： SCI
摘要： Muscle fiber diameter is an economically important trait because it affects meat yield and quality. However, the genetic basis underlying muscle fiber diameter has not been determined. In this study, we collected THREE muscular histological phenotypes in 479 ducks from an F-2 segregating population generated by mallard x Pekin duck crosses. We performed genome-wide association studies (GWAS) and identified a quantitative trait locus (QTL) significantly associated with muscle fiber diameter on chromosome 3. Then, we discovered the selection signatures using the fixation index among 40 mallards and 30 Pekin ducks in this QTL region. Furthermore, we characterized the recombination event in this QTL region and identified a 6-kb block located on TASP1 that was significantly associated with muscle fiber diameter. Finally, five SNPs were screened as potential causative mutations within the 6-kb block. In conclusion, we demonstrated that TASP1 contributes to an increase in muscle fiber diameter, which helps to characterize muscle development and contributes to the genetic improvement of meat yield and quality in livestock.
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