Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis
文献类型： 外文期刊
作者： Hu, Ya-Zhen 1 ; Wang, Ting 1 ; Wu, Chang-Song 1 ; Wang, Jie 1 ; Han, Xue-Qing 1 ; Zhang, Yong-An 1 ; Zhang, Xu-Jie 1 ;
作者机构： 1.Huazhong Agr Univ, Engn Res Ctr Green Dev Convent Aquat Biol Ind, Natl Key Lab Agr Microbiol,Coll Fisheries, Hubei Hongshan Lab,Yangtze River Econ Belt,Minist, Wuhan 430070, Peoples R China
2.Ningbo Univ, Sch Marine Sci, Ningbo 315832, Peoples R China
3.Huazhong Agr Univ, Shenzhen Inst Nutr & Hlth, Wuhan 430070, Peoples R China
4.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch,Genome Anal Lab,Minist Agr, Guangdong Lab Lingnan Modern Agr, Shenzhen 518000, Peoples R China
关键词： antimicrobial protein; FGF8; glycolysis; wound healing
期刊名称：ADVANCED SCIENCE （ 影响因子：14.1； 五年影响因子：15.6 ）
ISSN：
年卷期： 2025 年
页码：
收录情况： SCI
摘要： Repairing and preventing infections of skin wounds are crucial for the body health. Fibroblast growth factors (FGFs) have functions of repairing skin wounds, while antimicrobial peptides/proteins (AMPs) can prevent the infections of skin. Therefore, if FGFs can act like AMPs, they will have better application potential in promoting skin wound healing. Here, it is found that grass carp fibroblast growth factor 8a (gcFGF8a) has broad-spectrum and potent antibacterial activity through disrupting the cell membrane, indicating that FGF8 is an uncovered AMP. Further study revealed that gcFGF8a can accelerate skin wound healing through dual functions: inhibiting bacterial and activating of glycolysis. Mechanistically, gcFGF8a/FGFR4 signaling induces epithelial cell glycolytic programs for barrier remodeling through the mTORC1/HIF1 alpha pathway. Interestingly, it is found that mouse FGF8b (mFGF8b), the homolog of gcFGF8a, also has antibacterial and skin wound repair activities, indicating that FGF8 is a functionally conserved molecule in vertebrates. To the knowledge, FGF8 is the only member of the FGF family with both antibacterial and wound repair functions at present, greatly enriching the understanding of this pivotal molecule. Furthermore, these findings highlighted the potential application of FGF8 as a skin wound repair drug.
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