Schisandrin Protects against Norepinephrine-Induced Myocardial Hypertrophic Injury by Inhibiting the JAK2/STAT3 Signaling Pathway
文献类型： 外文期刊
作者： Yang, Min 1 ; Jiang, Xing-Can 2 ; Wang, Lei 1 ; Cui, Dong-An 2 ; Zhang, Jing-Yan 1 ; Wang, Xu-Rong 2 ; Feng, Hai-Peng; 1 ;
作者机构： 1.Engn & Technol Res Ctr Tradit Chinese Vet Med, Lanzhou, Gansu, Peoples R China
2.Chinese Acad Agr Sci CAAS, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou, Peoples R China
期刊名称：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE （ 影响因子：2.63； 五年影响因子：2.846 ）
ISSN： 1741-427X
年卷期： 2021 年 2021 卷
页码：
收录情况： SCI
摘要： Aims. Heart failure is closely associated with norepinephrine-(NE-) induced cardiomyocyte hypertrophy. Schisandrin is derived from the traditional Chinese medicine Schisandra; it has a variety of pharmacological activities, and the mechanism of schisandrin-mediated protection of the cardiovascular system is not clear. Main Methods. NE was used to establish a cardiomyocyte hypertrophy model to explore the mechanism of action of schisandrin. An MTT assay was used for cell viability; Hoechst fluorescence staining was used to observe the cell morphology and calculate the apoptosis rate. The cell surface area was measured and the protein to DNA ratio was calculated, changes in mitochondrial membrane potential were detected, and the degree of hypertrophic cell damage was evaluated. WB, QRT-PCR, and immunofluorescence were used to qualitatively, quantitatively, and quantitatively detect apoptotic proteins in the JAK2/STAT3 signaling pathway. Key Findings. In the NE-induced model, schisandrin treatment reduced the apoptosis rate of cardiomyocytes, increased the ratio of the cell surface area to cardiomyocyte protein/DNA, and also, increased the membrane potential of the mitochondria. The expression of both JAK2 and STAT3 was downregulated, and the BAX/Bcl-2 ratio was significantly reduced. In conclusion, schisandrin may protect against NE-induced cardiomyocyte hypertrophy by inhibiting the JAK2/STAT3 signaling pathway and reducing cardiomyocyte apoptosis.
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