Inhibitory effects of the anthocyanins from Lycium ruthenicum Murray on angiotensin-I-converting enzyme: in vitro and molecular docking studies
文献类型: 外文期刊
作者: Lu, Lu 2 ; Mi, Jia 2 ; Jin, Bo 2 ; Zhang, Lutao 2 ; Luo, Qing 2 ; Li, Xiaoying 2 ; Yan, Yamei 1 ; Cao, Youlong 1 ;
作者机构: 1.Ningxia Acad Agr & Forestry Sci, Inst Wolfberry Sci, Natl Wolfberry Engn Technol Res Ctr, Yinchuan 750000, Ningxia Hui, Peoples R China
2.Ningxia Acad Agr & Forestry Sci, Inst Wolfberry Sci, Natl Wolfberry Engn Technol Res Ctr, Yinchuan, Peoples R China
关键词: Lycium ruthenicum Murray; anthocyanin; angiotensin-converting enzyme; hypertension; molecular docking
期刊名称:JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE ( 影响因子:4.1; 五年影响因子:4.2 )
ISSN: 0022-5142
年卷期: 2023 年
页码:
收录情况: SCI
摘要: BACKGROUNDLycium ruthenicum Murray (LRM), a perennial shrub plant belonging to the Solanaceae family, is rich in anthocyanins, which have anti-inflammatory, antioxidant, lipid-lowering, intestinal flora regulating, and other pharmacological qualities. This study was primarily aimed to investigate the inhibitory effect of different anthocyanin purities from LRM on angiotensin-I-converting enzyme (ACE) activity in vitro. Moreover, the inhibitory mechanism was further analyzed by molecular docking technology. RESULTSTwo main anthocyanin isomers were identified by ultra-performance liquid chromatography-tandem mass spectrometry and proton/carbon-13 nuclear magnetic resonance, namely petunidin-3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-(& beta;-d-glucopyranoside) (trans-Pt3R5G) and petunidin-3-O-[rhamnopyranosyl-(cis-p-coumaroyl)]-5-O-(& beta;-d-glucopyranoside) (cis-Pt3R5G), with a molar ratio of 9:1. Three purification grades of Pt3R5G all showed excellent inhibitory effects on ACE, with the half maximal inhibitory concentration (IC50) values being 0.562, 0.421, and 0.106 mg & BULL;mL(-1). Increasing the purity may reduce the IC50 within a certain concentration range. An enzymatic kinetic experiment showed that the inhibitory effect of Pt3R5G on ACE was reversible and non-competitive: Pt3R5G and substrate were not in competition for the active sites of ACE. Molecular docking technology further revealed the possible mechanism was that Pt3R5G and ACE amino acid residues were interacting by hydrogen bonds to exert the inhibitory effect. CONCLUSIONThe results indicated that Pt3R5G from LRM was highly effective at inhibiting ACE activity in vitro, with the hydrogen bonds of Pt3R5G and ACE amino acid residues exerting the inhibition. As a potential plant-based ACE inhibitor, Pt3R5G can be used as a functional ingredient for antihypertensive effects. & COPY; 2023 Society of Chemical Industry.
- 相关文献
作者其他论文 更多>>
-
2-O-beta-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gutWei
作者:Dong, Wei;Peng, Yujia;Chen, Guijie;Xie, Zhiyong;Xu, Weiqi;Zhou, Wangting;Sun, Yi;Zeng, Xiaoxiong;Mi, Jia;Lu, Lu;Cao, Youlong;Yan, Yamei
关键词:Neuroinflammation; Gut microbiota; Leaky gut; Lipopolysaccharide; Fecal microbiome transplantation; 2O-beta-D-Glucopyranosyl-L-ascorbic acid
-
Effect of Lycium barbarum L. Root Restriction Cultivation Method on Plant Growth and Soil Bacterial Community Abundance
作者:He, Jun;Li, Xiaoying;He, Xinru;Qin, Ken;Cao, Youlong;Tian, Ying;Zhu, Lizhen
关键词:root-restriction cultivation; Lycium barbarum; nutrients; soil bacterial communities
-
Transcriptomics and Metabolomics Reveal the Critical Genes of Carotenoid Biosynthesis and Color Formation of Goji (Lycium barbarum L.) Fruit Ripening
作者:Wei, Feng;Wan, Ru;Shi, Zhigang;Li, Yunxiang;An, Wei;Qin, Ken;Cao, Youlong;Wei, Feng;Ma, Wenli;Wang, Hao;Chen, Yongwei;Bo, Jianhua
关键词:Lycium barbarum L; fruit ripening; fruit color; carotenoid; transcriptomics
-
A comprehensive review of goji berry processing and utilization
作者:Yu, Jing;Yu, Limei;Yan, Yamei;Zhang, Lutao;Mi, Jia;Lu, Lu;Luo, Qing;Li, Xiaoying;Zhou, Xuan;Cao, Youlong;Zhang, Fengfeng;Yan, Yamei;Zhang, Fengfeng
关键词:by-products; comprehensive utilization; efficacy components; goji berry; processing
-
A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice
作者:Zhou, Wangting;Liu, Peiyun;Xu, Weiqi;Zeng, Xiaoxiong;Ran, Linwu;Yan, Yamei;Lu, Lu;Cao, Youlong;Mi, Jia
关键词:
-
Development of Lycium barbarum-Forage Intercropping Patterns
作者:Zhu, Lizhen;Nan, Xiongxiong;Li, Yonghua;Li, Xiaoying;He, Jun;Liang, Xiaojie;Qin, Ken;Cao, Youlong;Zhou, Xiaoping;Wang, Fang;Wang, Fang;Zhao, Yan
关键词:Lycium barbarum-forage; intercropping pattern; land equivalent ratio; weighted mean; interspecific competitiveness
-
Anthocyanins from Lycium ruthenicum Murray Ameliorated High- Fructose Diet-Induced Neuroinflammation through the Promotion of the Integrity of the Intestinal Barrier and the Proliferation of Lactobacillus
作者:Peng, Yujia;Dong, Wei;Chen, Guijie;Xie, Zhiyong;Xu, Weiqi;Zhou, Wangting;Sun, Yi;Zeng, Xiaoxiong;Mi, Jia;Lu, Lu;Cao, Youlong;Yan, Yamei
关键词:Lycium ruthenicum murray; neuroinflammation; gut microbiota; anthocyanins; Lactobacillus