您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Liposome encapsulation for casein-derived peptides: Release behavior, in vitro digestibility, nutrient absorption, and gut microbiota

文献类型： 外文期刊

作者： Gong, Yining 1 ; Yuan, Dongdong 2 ; Zhan, Qiping 3 ; Ma, Zhangguo 4 ; Wang, Qin 4 ; Zhang, Shuwen 1 ; Pang, Xiaoyang 1 ; Wang, Yunna 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Food Sci & Technol, Beijing 100193, Peoples R China

2.Beijing Technol & Business Univ, Beijing Engn & Technol Res Ctr Food Addit, Sch Food & Hlth, Beijing 100048, Peoples R China

3.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China

4.Karamay lvcheng Agr Dev Co Ltd, Karamay 834000, Peoples R China

关键词： Casein peptide; Liposome; Encapsulation; Gastrointestinal stability; Nutrient absorption

期刊名称：FOOD CHEMISTRY-X （ 影响因子：8.2； 五年影响因子：8.2 ）

ISSN： 2590-1575

年卷期： 2025 年 29 卷

页码：

收录情况： SCI

摘要： Protein-derived bioactive peptides hold great potential for promoting health while face significant challenges during digestion, including structural degradation by gastrointestinal enzymes and limited stability, which hinder their effective utilization. Encapsulation technology offers a promising solution to protect bioactive peptides and ensure their targeted delivery. In this study, casein peptides (CP) were encapsulated into liposomes (CPL) prepared using the thin-film hydration method. The preparation conditions were optimized through response surface methodology, with the following parameters identified: a lecithin-to-cholesterol mass ratio of 3.0, a peptide solution concentration of 0.65 mg/mL, and a wall-to-core material volume ratio of 4.0. Validation experiments confirmed the optimized CPL formulation, resulting in liposomes with an average particle size of 86.13 +/- 0.62 nm and an encapsulation efficiency at 87.29 +/- 0.82 %. Comprehensive characterization of CPL was conducted using transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and fourier transform infrared spectroscopy (FTIR) techniques. The results demonstrated that CPL provided strong protection for CP against degradation by gastrointestinal enzymes, allowing controlled release in the intestine. This targeted release facilitated interactions with gut microbiota, leading to improved nutrient absorption and modulation of gut health. These findings highlight the potential of liposomal encapsulation to enhance the bioavailability and functional properties of bioactive peptides, paving the way for their broader application in health-related formulations.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台