文献类型： 外文期刊
作者： Peng, Xiaozhen 1 ; Yao, Xiaoqiao 2 ; Liu, Ya 2 ; Peng, Bangzhu 2 ;
作者机构： 1.Hunan Univ Med, Sch Publ Hlth & Lab Med, Huaihua 418000, Peoples R China
2.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China
3.Huazhong Agr Univ, Shenzhen Inst Nutr & Hlth, Wuhan 430070, Peoples R China
4.Chinese Acad Agr Sci, Guangdong Lab Lingnan Modern Agr, Genome Anal Lab,Shenzhen Branch, Minist Agr,Agr Genom Inst Shenzhen, Shenzhen 518120, Peoples R China
关键词： immunomodulatory; sodium hyaluronate; health drink; intestinal flora; immune deficiency
期刊名称：FOODS （ 影响因子：5.2； 五年影响因子：5.5 ）
ISSN：
年卷期： 2024 年 13 卷 6 期
页码：
收录情况： SCI
摘要： This study aimed to explore the immunomodulatory effects and mechanism of a sodium hyaluronate health drink in immunosuppressed mice. The results showed that the sodium hyaluronate health drink could improve thymus atrophy, repair spleen cell damage, promote the release of IL-2, IL-6 and TNF-alpha in serum, restore immune deficiency, and enhance immune function. In addition, 16s rRNA sequencing results of intestinal flora showed that different doses of health drink had different effects on the intestinal flora of mice. The low-dose group of mice showed a significant up-regulation of the abundance of Lactobacillus and promoted the formation of a new genus Akkermansia, while the medium- and high-dose group up-regulated the abundance of Lactobacillus and norank-f-Muribaculaceae, and stimulated the production of the new genus Alistipes. Sodium hyaluronate health drink may enhance the immune function of mice by changing the composition and abundance of intestinal flora, which provided a theoretical basis for the subsequent product development.
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