文献类型： 外文期刊

作者： Yuan, Ying ¹ ; Zhang, Wei-Yi ¹ ; Yang, Bai-Gao ¹ ; Zhou, Dong-Ke ¹ ; Xu, Lu ¹ ; He, Yong-Meng ¹ ; Zhang, Hao-Yuan ¹ ; Liu, Cheng-Li ¹ ; Ma, Yue-Hui ³ ; Chu, Ming-Xing ³ ; Zhang, Wen-Guang ⁴ ; Gao, Hui-Jiang ³ ; Jiang, Lin ³ ; Zhao, Fu-Ping ³ ; Zhang, Lu-Pei ³ ; Na, Ri-Su ⁴ ; Oyungerel, Baatarchogt ⁵ ; Han, Yan-Guo ¹ ; Zeng, Yan ¹ ; Wang, Shi-Zhi ¹ ; Jiang, Huai-Zhi ⁶ ; Zhang, Hong-Ping ⁷ ; Jiang, Xun-Ping ⁸ ; He, Jian-Ning ⁹ ; Liang, Hao ¹⁰ ; Kaushalendra, Kaushalendra ¹ ; Sun, Ya-Wang ¹ ; Huang, Yong-Fu ¹ ; Zhao, Yong-Ju ¹ ; Zhao, Zhong-Quan ¹ ; Guang-Xin, E. ¹ ;

作者机构： 1.Southwest Univ, Coll Anim Sci & Technol, Chongqing 400715, Peoples R China

2.Chongqing Key Lab Forage & Herbivore, Chongqing 400715, Peoples R China

3.Chinese Acad Agr Sci CAAS, Inst Anim Sci, Beijing 100193, Peoples R China

4.Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot 010018, Inner Mongolia, Peoples R China

5.Mongolian Univ Life Sci, Sch Anim Sci & Biotechnol, Ulaanbaatar 17024, Mongolia

6.Jilin Agr Univ, Anim Sci & Technol Coll, Changchun 130118, Jilin, Peoples R China

7.Sichuan Agr Univ, Coll Anim Sci & Technol, Farm Anim Genet Resources Explorat & Innovat Key L, Chengdu 611130, Sichuan, Peoples R China

8.Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Hubei, Peoples R China

9.Qingdao Agr Univ, Coll Anim Sci & Technol, Qingdao 266109, Shandong, Peoples R China

10.Inner Mongolia Univ, Sch Life Sci, State Key Lab Reprod Regulat & Breeding Grassland, Hohhot 010070, Inner Mongolia, Peoples R China; Mizoram Univ, Pachhunga Univ Coll, Dept Zool, Aizawl 796001, India

关键词： Boer goat; CNV; Muscle development; SMSCs

期刊名称：ZOOLOGICAL RESEARCH （ 影响因子：4.9； 五年影响因子：4.6 ）

ISSN： 2095-8137

年卷期： 2023 年 44 卷 2 期

页码：

收录情况： SCI

摘要： The Boer goat is one of the top meat breeds in modern animal husbandry and has attracted widespread attention for its unique growth performance. However, the genetic basis of muscle development in the Boer goat remains obscure. In this study, we identified specific structural variants in the Boer goat based on genome-wide selection signals and analyzed the basis of the molecular heredity of related candidate genes in muscle development. A total of 9 959 autosomal copy number variations (CNVs) were identified through selection signal analysis in 127 goat genomes. Specifically, we confirmed that the highest signal CNV (HSV) was a chromosomal arrangement containing an approximately 1.11 Mb (CHIR17: 60062304-61171840 bp) duplicated fragment inserted in reverse orientation and a 5 362 bp deleted region (CHIR17:60145940-60151302 bp) with overlapping genes (e.g., ARHGAP10, NR3C2, EDNRA, PRMT9, and TMEM184C). The homozygous duplicated HSV genotype (+/+) was found in 96% of Boer goats but was not detected in Eurasian goats and was only detected in 4% of indigenous African goats. The expression network of three candidate genes (ARHGAP10, NR3C2, and EDNRA) regulating dose transcription was constructed by RNA sequencing. Results indicated that these genes were involved in the proliferation and differentiation of skeletal muscle satellite cells (SMSCs) and their overexpression significantly increased the expression of SAA3. The HSV of the Boer goat contributed to superior skeletal muscle growth via the dose effects of overlapping genes.