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Network Analysis of Gut Microbial Communities Reveals Key Reason for Quercetin Protects against Colitis

文献类型： 外文期刊

作者： Lv, Yanan 1 ; Peng, Jing 1 ; Ma, Xiaoyu 1 ; Liang, Zeyi 1 ; Salekdeh, Ghasem Hosseini 3 ; Ke, Qunhua 1 ; Shen, Wenxiang 1 ; Yan, Zuoting 1 ; Li, Hongsheng 1 ; Wang, Shengyi 1 ; Ding, Xuezhi 1 ;

作者机构： 1.Chinese Acad Agr Sci, Key Lab Vet Pharmaceut Dev, Minist Agr & Rural Affairs, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Peoples R China

2.Inner Mongolia Agr Univ, Coll Vet Med, Hohhot 010010, Peoples R China

3.Agr Res Educ & Extens Org, Agr Biotechnol Res Inst Iran, Dept Syst Biol, Karaj 3135933151, Iran

4.Macquarie Univ, Dept Mol Sci, N Ryde, NSW 2109, Australia

5.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Peoples R China

关键词： quercetin; colitis; oxidative stress; inflammation; tight junction; gut microbiota

期刊名称：MICROORGANISMS （ 影响因子：4.2； 五年影响因子：4.6 ）

ISSN：

年卷期： 2024 年 12 卷 10 期

页码：

收录情况： SCI

摘要： As one of the most representative natural products among flavonoids, quercetin (QUE) has been reported to exhibit beneficial effects on gut health in recent years. In this study, we utilized a dextran sulfate sodium (DSS)-induced colitis mice model to explore the protective effects and underlying mechanisms of QUE on colitis. Our data demonstrated that QUE oral gavage administration significantly ameliorates the symptoms and histopathological changes associated with colitis. Additionally, the concentration of mucin-2, the number of goblet cells, and the expression of tight junction proteins (such as ZO-1, Occludin, and Claudin-1) were all found to be increased. Furthermore, QUE treatment regulated the levels of inflammatory cytokines and macrophage polarization, as well as the oxidative stress-related pathway (Nrf2/HO-1) and associated enzymes. Additionally, 16S rDNA sequencing revealed that QUE treatment rebalances the alterations in colon microbiota composition (inlcuding Bacteroidaceae, Bacteroides, and Odoribacter) in DSS-induced colitis mice. The analysis of network dynamics reveals a significant correlation between gut microbial communities and microenvironmental factors associated with inflammation and oxidative stress, in conjunction with the previously mentioned findings. Collectively, our results suggest that QUE has the potential to treat colitis by maintaining the mucosal barrier, modulating inflammation, and reducing oxidation stress, which may depend on the reversal of gut microbiota dysbiosis.

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