Biomimetic 2D-oriented microporous PLLA scaffolds: Fabrication and evaluation for bone repair
文献类型： 外文期刊
作者： Li, Yihong 1 ; Feng, Yanjun 3 ; Zhao, Zhixin 1 ; Liu, Lei 2 ; Li, Zhengqiu 1 ; Li, Jiafeng 3 ;
作者机构： 1.Xihua Univ, Sch Mat Sci & Engn, Chengdu 610039, Peoples R China
2.Lanzhou Univ, Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Chinese Acad Agr Sci,Coll Vet Med, Lanzhou 730000, Peoples R China
3.CCTEG, Coal Min Res Inst, Beijing, Peoples R China
4.State Key Lab Coal Min & Clean Utilizat, Beijing, Peoples R China
关键词： Poly ( L -lactic) acid; Two-dimensional oriented microporous; Bone tissue repair; Bionic structure
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2025 年 311 卷
页码：
收录情况： SCI
摘要： Poly(L-lactic) acid (PLLA) was limited in the application of bone repair materials due to its brittleness, poor melt strength and poor cellular affinity. In this work, single epoxy-terminated polydimethylsiloxane (e-PDMS) was used to extend the molecular chain of PLLA and improve the melt strength of PLLA. Subsequently, a uniform two-dimensional(2D) oriented microporous biomimetic structure was constructed by combining the biaxial orientation technology with the supercritical carbon dioxide (SC-CO2) foaming technology, which greatly improved the strength and toughness of PLLA (from 54.9 MPa,7.3 % to 133.6 MPa,72.6 %). This 2D oriented microporous PLLA was also more conducive to the expression of anti-inflammatory factors and pro-inflammatory factors simultaneously in mouse bone marrow macrophages (iBMDM), which had an effect on regulating inflammation. At the same time, this structure was also helpful to the adhesion and growth of mouse embryonic fibroblasts (NIH-3 T3), and can stimulate the activity of mouse embryonic osteoblast precursor cells (MC-3 T3-E1), showing good biocompatibility.
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