文献类型： 外文期刊
作者： Tang, Yan-Dong 1 ; Li, Yuming 4 ; Cai, Xue-Hui 1 ; Yin, Xin 1 ;
作者机构： 1.Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Harbin Vet Res Inst, Harbin 150069, Peoples R China
2.Chinese Acad Agr Sci, Heilongjiang Prov Res Ctr Vet Biomed, Harbin Vet Res Inst, Harbin 150069, Peoples R China
3.Chinese Acad Agr Sci, Heilongjiang Prov Key Lab Vet Immunol, Harbin Vet Res Inst, Harbin 150069, Peoples R China
4.Shandong First Med Univ & Shandong Acad Med Sci, Sch Publ Hlth, Jinan 250117, Peoples R China
5.Shandong First Med Univ & Shandong Acad Med Sci, Univ Shandong, Key Lab Emerging Infect Dis, Tai An 271000, Peoples R China
关键词： adaptation; attenuation; evolution; live attenuated vaccines (LAVs); pathogenicity
期刊名称：ADVANCED SCIENCE （ 影响因子：14.1； 五年影响因子：15.6 ）
ISSN：
年卷期： 2025 年 12 卷 3 期
页码：
收录情况： SCI
摘要： Viral infections continue to pose a significant threat to the health of both humans and animals. Currently, live attenuated vaccines (LAVs) remain the most efficacious and widely utilized tool for combating viral infections. Conventional LAVs involve the adaptation of virulent viruses to novel hosts, cell cultures, or suboptimal environments, resulting in a reduction in pathogenicity while retaining immunogenicity. This process entails directed evolution of the virus to enhance its replication efficiency under these modified conditions. In this review, the development of traditional animal-adapted and cold-adapted LAVs is specially discussed. Additionally, the factors that contribute to virus attenuation from a viral lifecycle perspective are summarized. Finally, we propose future directions for next-generation LAVs.
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