Antimicrobial and Antibiofilm Activity of Marine Streptomyces sp. NBUD24-Derived Anthraquinones Against MRSA
文献类型： 外文期刊
作者： Yang, Yuxin 1 ; Zhou, Zhiyan 1 ; Huang, Guobao 1 ; Yang, Shuhua 1 ; Mao, Ruoyu 2 ; Ding, Lijian 1 ; Wang, Xiao 1 ;
作者机构： 1.Ningbo Univ, Hlth Sci Ctr, Ningbo 315211, Peoples R China
2.Chinese Acad Agr Sci, Feed Res Inst, Gene Engn Lab, Beijing 100081, Peoples R China
关键词：
marine natural products;
期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.6 ）
ISSN：
年卷期： 2025 年 23 卷 8 期
页码：
收录情况： SCI
摘要： Antimicrobial resistance (AMR) has emerged as a global health crisis, with methicillin-resistant Staphylococcus aureus (MRSA) representing one of the most clinically significant multidrug-resistant pathogens. In this study, three structurally unique anthracycline derivatives-keto-ester (1), 4-deoxy-epsilon-pyrromycinone (2), and misamycin (3)-were first isolated and characterized from the fermentation broth of the marine-derived Streptomyces tauricus NBUD24. These compounds exhibited notable antibacterial efficacy against MRSA, with minimum inhibitory concentrations (MICs) ranging from 16 to 32 mu g/mL. Cytotoxicity assays confirmed their safety profile at therapeutic concentrations. The biofilm formation assay demonstrated that 4-deoxy-epsilon-pyrromycinone inhibited biofilm formation of MRSA ATCC43300, with an inhibition rate of 64.4%. Investigations of antibacterial mechanisms revealed that these compounds exert antibacterial effects primarily through disruption of bacterial cell wall integrity and destruction of DNA structure. These findings underscore the potential of marine-derived microbial metabolites as promising scaffolds for developing next-generation antimicrobial candidates to combat drug-resistant infections.
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