Recent advances in antimicrobial lipopeptide fengycin secreted by Bacillus: Structure, biosynthesis, antifungal mechanisms, and potential application in food preservation
文献类型: 外文期刊
作者: Chen, Mengling 1 ; Wang, Hui 1 ; Zhang, Chuang 2 ; Zhang, Yue 4 ; Sun, Hao 3 ; Yu, Lu 3 ; Zhang, Qiuqin 1 ; Chen, Xiaohong 2 ; Xiao, Hongmei 1 ;
作者机构: 1.Nanjing Agr Univ, Sanya Inst, Sanya 572025, Peoples R China
2.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China
3.Nanjing Agr Univ, Coll Sci, Nanjing 210095, Peoples R China
4.CAAS, Inst Food Sci & Technol, Beijing 100193, Peoples R China
关键词: Lipopeptides; Fengycin; Biological activity; Bacillus; Antifungal compound
期刊名称:FOOD CHEMISTRY ( 影响因子:9.8; 五年影响因子:9.7 )
ISSN: 0308-8146
年卷期: 2025 年 489 卷
页码:
收录情况: SCI
摘要: Fengycin, a cyclic lipopeptide generated by Bacillus, is a potent biocontrol agent against plant diseases. Compared with chemical antibiotics, fengycin exhibits high antifungal efficiency with low toxicity and great biodegradability, making it a promising alternatives to antibiotics. The structure and biosynthesis of fengycin are briefly covered in this review. The antifungal mechanisms of fengycin are mainly outlined as follows: (1) degrading the cell wall integrity; (2) disrupting cell membranes; (3) interfering with intracellular metabolism; (4) inducing programmed cell death and autophagy; and (5) inducing defense response in plants. Ultimately, a summary of fengycin's applications in fruits and vegetables preservation is provided. This comprehensive knowledge encourages the commercial use of fengycin and offers a foundation for in-depth research into molecular mechanism, which contributes to modifying the structure of fengycin and designing fengycin analogues with more stable chemical properties and higher biological activity.
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