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The combined effects of 2′-fucosyllactose and 6′-sialyllactose on immune function and gut microbiota in healthy mice

文献类型： 外文期刊

作者： Feng, Kejue 1 ; Lin, Zicun 1 ; Du, Jinhui 1 ; Xu, Zhenxia 2 ; Xiang, Xia 2 ; Shi, Hao 1 ;

作者机构： 1.Hubei Engn Res Ctr Biosynth Nutr Chem, 999 Gaoxin Ave, Wuhan East Lake High-tech Dev Zone, Wuhan 430075, Peoples R China

2.Chinese Acad Agr Sci, Oil Crops Res Inst, Wuhan 430062, Peoples R China

关键词： 2 ' -fucosyllactose; 6 ' -sialyllactose; Immune regulation; Intestinal microbiota

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）

ISSN： 2212-4292

年卷期： 2025 年 71 卷

页码：

收录情况： SCI

摘要： 2 '-Fucosyllactose (2 '-FL) and 6 '-sialyllactose (6 '-SL) are major components of human milk oligosaccharides (HMOs) known for their roles in immune regulation. This study investigated the combined effects of 2 '-FL and 6 ' SL on immune function and gut microbiota composition in healthy mice. BALB/c mice were orally administered 2 '-FL alone or in combination with 6 '-SL for 30 days. Immune function was assessed by delayed-type hypersensitivity (DTH) response, carbon clearance test, macrophage phagocytosis, lymphocyte proliferation and natural killer (NK) cell activity. Gut microbiota composition and short-chain fatty acids (SCFAs) contents were analyzed. Combined supplementation significantly enhanced immune function. Specifically, DTH responses increased by 60.9 % and 41.7 %, lymphocyte proliferation by 22.5 % and 47.5 %, carbon particle clearance rates by 12.67 % and 14.89 %, and NK cell cytotoxicity by 111.1 % and 128.1 % in the low- and high-dose groups, respectively. Particularly, the combination exerted a more pronounced immunomodulatory effect compared to 2 '-FL alone. In terms of gut microbiota, 16S rRNA sequencing showed that the combination led to increased microbial diversity and selectively enriched beneficial taxa such as unclassified_Clostridia_UCG_014 (1.1- and 1.9fold) and Bacteroides (1.6- and 2.1-fold), while reducing potentially unfavorable genera like uncultured_rumen_bacterium and Ruminococcus. Moreover, the combination markedly enhanced the generation of SCFAs, including acetic, propionic, isobutyric, butyric, isovaleric, and valeric acids, especially greater increases in acetic acid and isovaleric acid compared to 2 '-FL alone, indicating enhanced microbial fermentation activity that may contribute to immune modulation. These findings highlight the potential of combined 2 '-FL and 6 '-SL cosupplementation as a functional strategy for immune health through microbiota-mediated mechanisms.

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