文献类型： 外文期刊
作者： Mo, Futao 1 ; Sun, Weibo 1 ; Zhang, Liping 1 ; Zhang, Xiaoyan 1 ; La, Yongfu 3 ; Xiao, Fan 1 ; Jia, Jianlei 4 ; Jin, Jipe 1 ;
作者机构： 1.Gansu Agr Univ, Coll Anim Sci & Technol, 1 Yingmen Village, Lanzhou 730070, Gansu, Peoples R China
2.Gansu Grassland Tech Extens Stn, Lanzhou, Peoples R China
3.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Anim Sci Dept, Lanzhou, Peoples R China
4.Qinghai Univ, Key Lab Plateau Ecol & Agr, Xining, Peoples R China
关键词： BMPRIB; litter size; sheep; SNPs; allele distribution
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.271； 五年影响因子：1.697 ）
ISSN： 1049-5398
年卷期：
页码：
收录情况： SCI
摘要： The BMPRIB gene belongs to the TGF-beta superfamily and is considered to be a regulator of sheep reproductive performance. Single nucleotide polymorphisms (SNPs) of BMPRIB gene in the Small Tail Han, Hu, Mongolian, Oula, Gansu Alpine Fine-wool, Dorper and Australian White sheep were detected by Sanger sequencing. Five SNPs (rs427897187 G > A, rs418841713 A > G, rs159952533 T > C, rs429416173 C > A and rs403555643 A > G) of BMPRIB gene were identified. For rs427897187 G > A, further analysis revealed that genotype GG and GA had 0.26 (p < 0.05) and 0.33 (p < 0.05) litter size less than those with genotype AA in Oula sheep. For rs403555643 A > G, further analysis revealed that genotype GG and AG had 0.65 (p < 0.05) and 0.38 (p < 0.05) litter size more than those with genotype AA in Oula sheep, and genotype GG had 0.56 (p < 0.05) litter size more than those with genotype AA in Mongolian sheep. The results showed that rs427897187 G > A and rs403555643 A > G are potential molecular markers wich could improve litter size of Chinese indigenous sheep and be used in Chinese indigenous sheep breeding.
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