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Integrated Multi-Omics of the Longissimus Dorsal Muscle Transcriptomics and Metabolomics Reveals Intramuscular Fat Accumulation Mechanism with Diet Energy Differences in Yaks

文献类型： 外文期刊

作者： Deng, Jingying 1 ; Bao, Pengjia 1 ; Li, Ning 3 ; Kong, Siyuan 4 ; Wang, Tong 1 ; Zhang, Minghao 1 ; Yu, Qinran 1 ; Cao, Xinyu 2 ; Jia, Jianlei 1 ; Yan, Ping 1 ;

作者机构： 1.Lanzhou Inst Husb & Pharmaceut Sci, Chinese Acad Agr Sci, Lanzhou 730050, Peoples R China

2.Qinghai Univ, Coll Agr & Anim Husb, Xining 810016, Peoples R China

3.Chinese Acad Agr Sci, Inst Western Agr, Changji 831100, Peoples R China

4.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen 518000, Peoples R China

关键词： yak; longissimus dorsal muscle; intramuscular fat deposition; transcriptomics; lipid metabolomics

期刊名称：BIOMOLECULES （ 影响因子：4.8； 五年影响因子：5.6 ）

ISSN：

年卷期： 2025 年 15 卷 7 期

页码：

收录情况： SCI

摘要： IMF (intramuscular fat, IMF), as a key index for evaluating meat quality traits (shear force and cooking loss, etc.), and its deposition process are jointly regulated by nutritional and genetic factors. In this study, we analyzed the molecular regulation mechanism of IMF deposition in the LD (longissimus dorsal muscle, LD) by dietary energy level in Pamir yaks. Meat quality assessment showed that the meat quality of the High-energy diet group (1.53 MJ/Kg, G) and the Medium-energy diet group (1.38 MJ/Kg, Z) were significantly improved compared with that of the Low-energy diet group (0.75 MJ/Kg, C), in which IMF content in the LD of yaks in G group was significantly higher (p < 0.05) compared with Z and C groups. Further analysis by combined transcriptomics and lipid metabolomics revealed that the differences in IMF deposition mainly originated from the metabolism of lipids, such as TG (triglycerides, TG), PS (phosphatidylserine, PS), and LPC (lysophosphatidylcholine, LPC), and were influenced by SFRP4, FABP4, GADD45A, PDGFRA, RBP4, and DGAT2 genes, further confirming the importance of lipid-gene interactions in IMF deposition. This study reveals the energy-dependent epigenetic regulatory mechanism of IMF deposition in plateau ruminants, which provides molecular targets for optimizing yak nutritional strategies and quality meat production, while having important theoretical and practical value for the sustainable development of livestock husbandry on the Tibetan Plateau.

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