文献类型： 外文期刊
作者： Li, Wangchang 2 ; Li, Henggang 1 ; Yang, Chunyan 1 ; Zheng, Haiying 1 ; Duan, Anqin 1 ; Huang, Liqing 1 ; Feng, Chao 1 ; Yang, Xiaogan 2 ; Shang, Jianghua 1 ;
作者机构： 1.Chinese Acad Agr Sci, Guangxi Buffalo Res Inst, Guangxi Key Lab Buffalo Genet Reprod & Breeding, Nanning 530001, Peoples R China
2.Guangxi Univ, Coll Anim Sci & Technol, Guangxi Key Lab Anim Breeding Dis Control & Preven, Nanning 530004, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Buffalo Genet Breeding & Reprod Technol, Nanning 530001, Peoples R China
关键词： buffalo; milk production traits; genome-wide association study
期刊名称：GENES （ 影响因子：2.8； 五年影响因子：3.2 ）
ISSN：
年卷期： 2025 年 16 卷 2 期
页码：
收录情况： SCI
摘要： Background: Buffaloes are considered an indispensable genetic resource for dairy production. However, improvements in lactation performance have been relatively limited. Advances in sequencing technology, combined with genome-wide association studies, have facilitated the breeding of high-quality buffalo. Methods: We conducted an integrated analysis of genomic sequencing data from 120 water buffalo, the high-quality water buffalo genome assembly designated as UOA_WB_1, and milk production traits, including 305-day milk yield (MY), peak milk yield (PM), total protein yield (PY), protein percentage (PP), fat percentage (FP), and total milk fat yield (FY). Results: The results identified 56 significant SNPs, and based on these markers, 54 candidate genes were selected. These candidate genes were significantly enriched in lactation-related pathways, such as the cAMP signaling pathway (ABCC4), TGF-beta signaling pathway (LEFTY2), Wnt signaling pathway (CAMK2D), and metabolic pathways (DGAT1). Conclusions: These candidate genes (e.g., ABCC4, LEFTY2, CAMK2D, DGAT1) provide a substantial theoretical foundation for molecular breeding to enhance milk production in buffaloes.
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