Metabolites Discovery from Streptomyces xanthus: Exploring the Potential of Desert Microorganisms
文献类型： 外文期刊
作者： Luo, Xinrong 1 ; Liu, Zhanwen 1 ; Xia, Zhanfeng 1 ; Luo, Xiaoxia 1 ; Zhang, Juan 2 ; Chen, Ailiang 2 ; Wang, Haoxin 3 ; Wan, Chuanxing 1 ; Zhang, Lili 1 ;
作者机构： 1.Tarim Univ, Coll Life Sci & Technol, State Key Lab Incubat Base Conservat & Utilizat Bi, Alar 843300, Peoples R China
2.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Key Lab Agroprod Qual & Safety, Beijing 100081, Peoples R China
3.Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China
关键词： actinomycete; polyphasic taxonomy; genomics; metabolomics; thiolutin; Taklamakan desert
期刊名称：BIOLOGY-BASEL （ 影响因子：3.5； 五年影响因子：4.0 ）
ISSN：
年卷期： 2025 年 14 卷 2 期
页码：
收录情况： SCI
摘要： The Taklamakan Desert is an extreme environment supporting a unique and diverse microbial community with significant potential for exploration. Strain TRM70308T, isolated from desert soil, shares 98.43% 16S rRNA gene sequence similarity with Streptomyces alkaliterrae OF1T. Polyphasic taxonomy confirmed TRM70308T as a novel species, named Streptomyces xanthus. Genomic analysis revealed that only one of the strain's 25 biosynthetic gene clusters (BGCs) formed a cluster of gene families (CGFs) within the MIBiG database, emphasizing its genomics uniqueness. LC-MS/MS and Feature-Based Molecular Networking (FBMN) identified 33 metabolites across various categories, including alkaloids, saponins, benzoic acids, and benzofurans, most of which remain uncharacterized. Further chemical investigation led to the isolation of one novel compound, aconicarpyrazine C, and four known compounds: thiolutin, dibutyl phthalate, bis(2-ethylhexyl) phthalate, and N-acetyltryptamine. Thiolutin exhibited strong activity against five local fungal pathogens that cause plant diseases, with a production yield of 270 mg/L. These results establish a foundation for pilot-scale thiolutin production and its potential development as an antifungal agent for agricultural applications. Our findings highlight deserts as a valuable source of novel actinomycetes and bioactive natural products with immense potential for future research and development.
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