A cis-Regulatory Mutation of PDSS2 Causes Silky-Feather in Chickens
文献类型: 外文期刊
第一作者: Feng, Chungang
作者: Feng, Chungang;Gao, Yu;Song, Chi;Gu, Xiaorong;Li, Qingyuan;Li, Jinxiu;Liu, Tongxin;Zhao, Yiqiang;Wang, Yanqiang;Fei, Jing;Hu, Xiaoxiang;Li, Ning;Feng, Chungang;Gu, Xiaorong;Li, Qingyuan;Li, Jinxiu;Liu, Tongxin;Zhao, Yiqiang;Fei, Jing;Hu, Xiaoxiang;Li, Ning;Feng, Chungang;Dorshorst, Ben;Rubin, Carl-Johan;Andersson, Leif;Dorshorst, Ben;Song, Chi;Li, Huifang;Chen, Kuanwei;Qu, Hao;Shu, Dingming;Ashwell, Chris;Da, Yang;Andersson, Leif;Li, Ning
作者机构:
期刊名称:PLOS GENETICS ( 影响因子:5.917; 五年影响因子:6.284 )
ISSN: 1553-7404
年卷期: 2014 年 10 卷 8 期
页码:
收录情况: SCI
摘要: Silky-feather has been selected and fixed in some breeds due to its unique appearance. This phenotype is caused by a single recessive gene (hookless, h). Here we map the silky-feather locus to chromosome 3 by linkage analysis and subsequently fine-map it to an 18.9 kb interval using the identical by descent (IBD) method. Further analysis reveals that a C to G transversion located upstream of the prenyl (decaprenyl) diphosphate synthase, subunit 2 (PDSS2) gene is causing silky-feather. All silky-feather birds are homozygous for the G allele. The silky-feather mutation significantly decreases the expression of PDSS2 during feather development in vivo. Consistent with the regulatory effect, the C to G transversion is shown to remarkably reduce PDSS2 promoter activity in vitro. We report a new example of feather structure variation associated with a spontaneous mutation and provide new insight into the PDSS2 function.
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