Schisandra chinensis (Turcz.) Baill. polysaccharide inhibits influenza A virus in vitro and in vivo

文献类型： 外文期刊

第一作者： Qi, Jing

作者： Qi, Jing;Zhou, Yifa;Qi, Jing;Lv, Chaoxiang;Guo, Jin;Li, Yuanguo;Sima, Mingwei;Luo, Rongbo;Xiang, Haiyang;Xia, Xianzhu;Wang, Tiecheng;Lv, Chaoxiang;Guo, Jin;Sima, Mingwei;Wang, Tiecheng;Zhou, Yifa

作者机构：

关键词： antiviral; immunomodulation; inflammation; influenza; polysaccharides

期刊名称：FEBS OPEN BIO （ 影响因子：2.6； 五年影响因子：2.5 ）

ISSN： 2211-5463

年卷期： 2023 年 13 卷 10 期

页码：

收录情况： SCI

摘要： Influenza virus is prone to seasonal spread and widespread outbreaks, which pose important challenges to public health security. Therefore, it is important to effectively prevent and treat influenza virus infection. Schisandra polysaccharide (SPJ) is a polysaccharide derived from the fruit of Schisandra chinensis (Turcz.) Baill. In this study, we evaluated the antiviral activity of SPJ in vitro and in vivo, especially against influenza A virus (IAV) infection. By analyzing SPJ structure and monosaccharide composition, the molecular weight of SPJ was determined to be 115.5 KD, and it is composed of galacturonic acid (89.4%), rhamnose (0.8%), galactose (4.4%), arabinose (3.8%), and glucose (1.7%). Immunofluorescence analysis showed that SPJ treatment reduced the positive rate of viral nucleoproteins in cells, indicating that the compound had an inhibitory effect on influenza virus replication. Furthermore, SPJ therapy improved the survival of infected mice. Lung virus titer assays indicated that SPJ treatment significantly reduced viral loading in the lung tissue of infected mice and alleviated the pathological damage caused by influenza virus infection. Moreover, SPJ reduced cytokine expression during influenza virus challenge. In conclusion, SPJ has anti-influenza virus effects and may have potential as an anti-influenza drug candidate in further clinical studies.

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