Yeast cell-wall polysaccharides improve immunity and attenuate inflammatory response via modulating gut microbiota in LPS-challenged laying hens

文献类型： 外文期刊

第一作者： Zhou, Jianmin

作者： Zhou, Jianmin;Fu, Yu;Qi, Guanghai;Zhang, Haijun;Wang, Jing;Wu, Shugeng;Dai, Jinjun;Wang, Jing

作者机构：

关键词： Yeast cell wall polysaccharides; Immunity; Inflammatory response; Gut microbiota; Laying hen

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2023 年 224 卷

页码：

收录情况： SCI

摘要： Effects of dietary supplementation of yeast cell-wall polysaccharides (YCWP) on production performance, ileal microbial composition, immunomodulatory and anti-inflammatory effects in LPS-challenged laying hens, were evaluated. A total of 288 35-week-old Hy-Line Brown layers were randomly assigned into 4 dietary treatments: 0, 250, 500 and 1000 mg/kg YCWP, respectively. After a 12-week feeding period, a total of 32 birds were selected from the control (n = 16) and 1000 mg/kg YCWP group (n = 16). For each group, half (n = 8) received Escherichia coli LPS and half (n = 8) received PBS at 1 mg/kg body weight, intravenously. Results showed that YCWP enhanced feed efficiency and egg production linearly, with optimal laying performance notable in the 1000 mg/kg YCWP group. Dietary YCWP enhanced serum IgM and expression of ileal avian beta-defensin, allevi-ated the LPS-induced elevated levels of serum IL-6 and IL-1 beta and the up-regulated expression of IL-1 beta, TNF-alpha, IFN-gamma, and IL-6 in spleen and/or ileal mucosa. Furthermore, anti-inflammatory and immunomodulatory effects of YCWP were linked with its enhancement effect on microbial diversity, proliferation of Bifidobacteriaceae, Lac-tocillus, Candidatus_Arthromitus, Streptomyces, Bacillaceae, and Desulfovibrio, and reduced abundance of Shigella. Therefore, YCWP has the potentials to be utilized as safe prebiotics and gut enhancer in laying hens.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序